5-Bromo-2-Hydroxypyrimidine: Technical Guide & Application Insights
Table of Contents
1. Product Overview & Specifications
Basic Parameters
| Parameter | 5-Bromo-2-Hydroxypyrimidine | Comparable Compound (e.g., 5-Chloro-2-Hydroxypyrimidine) |
|---|---|---|
| CAS Number | 15862-52-7 | N/A |
| Molecular Formula | C4H3BrN2O | C4H3ClN2O |
| Molecular Weight | 191.98 g/mol | 146.53 g/mol |
| Purity | ≥98% (HPLC) | ≥95% |
| Solubility | DMSO, Methanol | Limited in polar solvents |
2. Key Applications & Industrial Uses
Pharmaceutical Intermediates
Critical building block for antiviral agents and kinase inhibitors.
Organic Synthesis
Preferred catalyst in cross-coupling reactions (Suzuki, Buchwald-Hartwig).
Agrochemical Development
Core component in next-generation fungicides and herbicides.
3. Operational Guidelines & Best Practices
Suzuki Coupling Protocol
- Prepare 1M solution in anhydrous DMSO
- Use Pd(PPh3)4 (2 mol%) as catalyst
- Maintain reaction at 80°C under N2
4. Real-World Use Cases
Anticancer Drug Development
Used in synthesis of Bruton’s tyrosine kinase (BTK) inhibitors with 92% yield improvement.
5. Client Success Stories
PharmaCorp Ltd. (2023)
Achieved 40% cost reduction in Darunavir intermediate production through optimized bromination.
AgroScience Co. (2024)
Developed broad-spectrum fungicide with 78% field efficacy using our compound.
6. Request Customized Solutions
Contact our technical team for batch-specific specifications or custom synthesis:
Email: info@vivalr.com
Tel: (86) 15866781826
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