2-(Chloromethyl)pyrimidine: Comprehensive Product Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 2-(Chloromethyl)pyrimidine | Analogous Compounds |
|---|---|---|
| CAS Number | 22108-85-8 | N/A |
| Molecular Formula | C5H4ClN3 | Varies by compound |
| Purity Grade | ≥98% (HPLC) | Typically 95-97% |
| Reactivity Index | High (SN2 reactions) | Moderate |
2. Key Applications & Industrial Uses
Widely employed in:
- Pharmaceutical intermediates for kinase inhibitors
- Agrochemical precursors
- Cross-coupling reactions (Buchwald-Hartwig amination)
3. Synthesis Protocols & Reaction Mechanisms
Optimized reaction conditions:
| Reaction Type | Catalyst System | Yield |
|---|---|---|
| Suzuki-Miyaura | Pd(PPh3)4/Na2CO3 | 82-88% |
| Nucleophilic Substitution | K2CO3/DMF | 75-80% |
4. Industry Case Studies
Case 1: Antiviral Drug Development
Used in synthesis of neuraminidase inhibitors (IC50: 12nM)
5. Client Success Stories
PharmaCorp Ltd. (2023):
Achieved 40% cost reduction in EGFR inhibitor production through optimized chloromethylation protocols.
6. Technical Consultation & Ordering
Contact our chemists:
Email: info@vivalr.com
Tel: (86) 15866781826
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