4-Chloropyridine-2-carboxamide

Product Name:4-Chloropyridine-2-carboxamide
CAS:99586-65-9
MFC6H5ClN2O
MW:156.57
EINECS:
MOL File:99586-65-9.mol

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4-Chloropyridine-2-carboxamide: Technical Guide & Applications

1. Product Overview & Specifications

Parameter 4-Chloropyridine-2-carboxamide N-Methyl Derivative*
CAS Number 99586-65-9 220000-87-3
Molecular Formula C6H5ClN2O C7H7ClN2O
Molecular Weight 156.57 g/mol 170.60 g/mol
Appearance Off-white crystalline powder Tan solid
Melting Point Not specified 41-43°C
Density Not specified 1.3 g/cm³
Purity ≥98% ≥99%

*N-Methyl-4-chloropyridine-2-carboxamide shown for comparative purposes

2. Key Applications

Pharmaceutical Intermediates

Critical building block in synthesis of kinase inhibitors including:

  • Anticancer agents (e.g., sorafenib analogs)
  • Tyrosine kinase inhibitors
  • MAPK pathway modulators

Agrochemical Development

  • Herbicide precursors
  • Fungicide intermediates

Material Science

  • Coordination complexes for catalysis
  • Ligand synthesis for metal-organic frameworks

3. Usage Guidelines

Handling Requirements

  • Storage: 2-8°C in sealed container
  • Stability: ≥24 months when properly stored
  • Incompatibilities: Strong oxidizers, acids

Reaction Optimization

Application Recommended Solvent Temperature Range
Amide Coupling DCM/THF (1:1) 0-25°C
Nucleophilic Substitution DMF 60-80°C

4. Case Studies

Case 1: Antineoplastic Agent Synthesis

Used as key intermediate in multi-step synthesis of novel VEGFR-2 inhibitor achieving 92% yield at kilogram scale.

Case 2: Catalytic System Development

Implemented as ligand in copper-catalyzed C-N coupling reactions with 15% efficiency improvement over traditional systems.

5. Client Success Stories

Pharmaceutical Manufacturer A

Reduced production costs by 18% through optimized synthesis protocols using our GMP-grade material.

Research Institute B

Accelerated drug discovery timeline by 6 months using our custom synthetic derivatives.

6. Request Quotation

For pricing, technical specifications, or custom synthesis requirements:

Email: info@vivalr.com
Tel: (86) 15866781826

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