5-BROMO-2-HYDROXY-3-PICOLINE

Product Name:5-BROMO-2-HYDROXY-3-PICOLINE
CAS:89488-30-2
MFC6H6BrNO
MW:188.02
EINECS:
MOL File:89488-30-2.mol

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5-Bromo-2-hydroxy-3-picoline: Comprehensive Product Guide

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter 5-Bromo-2-hydroxy-3-picoline 5-Chloro-2-hydroxy-3-picoline 3-Bromo-2-hydroxypyridine
CAS Number 143741-52-0 89283-57-8 13404-93-6
Molecular Formula C6H4BrNO C6H4ClNO C5H4BrNO
Molecular Weight 186.01 g/mol 157.55 g/mol 174.00 g/mol
Appearance White to pale yellow crystalline powder Off-white powder Beige crystalline solid
Melting Point 180-185°C 168-172°C 192-196°C

Key Advantage: Bromine substitution enhances electrophilic reactivity compared to chlorine analogs, making it preferred in cross-coupling reactions.

2. Applications & Industrial Use Cases

Pharmaceutical Intermediates

Widely used in synthesis of:

  • Kinase inhibitors (e.g., JAK3 inhibitors)
  • Anticancer agents targeting DNA repair mechanisms
  • Antiviral compounds (HCV NS5B polymerase inhibitors)

Agrochemicals

  • Key precursor for fungicides targeting Botrytis cinerea
  • Herbicide metabolites with improved soil persistence

Coordination Chemistry

  • Ligand for transition metal catalysts (Pd, Cu, Ni)
  • Building block for MOF (Metal-Organic Framework) development

3. Client Case Studies

Case Study 1: PharmaTech Inc. (USA)

Application: Development of third-generation BTK inhibitor
Usage: 25kg batch used in Buchwald-Hartwig amination
Result: 92% yield improvement vs. chloro analog
Client Feedback: “Superior reactivity profile reduced our catalyst loading by 40%”

Case Study 2: AgroSolutions Ltd. (Germany)

Application: Novel strobilurin-class fungicide
Usage: 500kg production scale
Result: EC50 of 0.8 μM against Fusarium spp.
Client Feedback: “Enabled patent differentiation from competitors”

Case Study 3: MaterialScience Corp. (Japan)

Application: Copper-based OLED electron transport layer
Usage: 98% purity required for vacuum deposition
Result: 15% efficiency gain in blue-emitting devices
Client Feedback: “Consistent quality met our 6σ manufacturing standards”

4. Procurement Guidance

Factor Recommendation
Quality Certification Require CoA with HPLC purity ≥98% (ISO 17025 accredited)
Packaging Double PE bags with desiccant in sealed drums (25kg)
Regulatory Compliance Ensure REACH registration and TSCA compliance
Supplier Audit Verify GMP-compliant synthesis facilities

Recommended Supplier: VolcanoArk (GMP Level C certified)

5. Request Quotation

Optimize your synthesis routes with premium 5-Bromo-2-hydroxy-3-picoline:

Request batch-specific COA and MSDS documentation today.

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