5-Bromo-2-hydroxy-3-picoline: Comprehensive Product Guide
Table of Contents
- 1. Product Specifications & Comparative Analysis
- 2. Applications & Industrial Use Cases
- 3. Client Case Studies
- 4. Procurement Guidance
- 5. Request Quotation
1. Product Specifications & Comparative Analysis
| Parameter | 5-Bromo-2-hydroxy-3-picoline | 5-Chloro-2-hydroxy-3-picoline | 3-Bromo-2-hydroxypyridine |
|---|---|---|---|
| CAS Number | 143741-52-0 | 89283-57-8 | 13404-93-6 |
| Molecular Formula | C6H4BrNO | C6H4ClNO | C5H4BrNO |
| Molecular Weight | 186.01 g/mol | 157.55 g/mol | 174.00 g/mol |
| Appearance | White to pale yellow crystalline powder | Off-white powder | Beige crystalline solid |
| Melting Point | 180-185°C | 168-172°C | 192-196°C |
Key Advantage: Bromine substitution enhances electrophilic reactivity compared to chlorine analogs, making it preferred in cross-coupling reactions.
2. Applications & Industrial Use Cases
Pharmaceutical Intermediates
Widely used in synthesis of:
- Kinase inhibitors (e.g., JAK3 inhibitors)
- Anticancer agents targeting DNA repair mechanisms
- Antiviral compounds (HCV NS5B polymerase inhibitors)
Agrochemicals
- Key precursor for fungicides targeting Botrytis cinerea
- Herbicide metabolites with improved soil persistence
Coordination Chemistry
- Ligand for transition metal catalysts (Pd, Cu, Ni)
- Building block for MOF (Metal-Organic Framework) development
3. Client Case Studies
Case Study 1: PharmaTech Inc. (USA)
Application: Development of third-generation BTK inhibitor
Usage: 25kg batch used in Buchwald-Hartwig amination
Result: 92% yield improvement vs. chloro analog
Client Feedback: “Superior reactivity profile reduced our catalyst loading by 40%”
Case Study 2: AgroSolutions Ltd. (Germany)
Application: Novel strobilurin-class fungicide
Usage: 500kg production scale
Result: EC50 of 0.8 μM against Fusarium spp.
Client Feedback: “Enabled patent differentiation from competitors”
Case Study 3: MaterialScience Corp. (Japan)
Application: Copper-based OLED electron transport layer
Usage: 98% purity required for vacuum deposition
Result: 15% efficiency gain in blue-emitting devices
Client Feedback: “Consistent quality met our 6σ manufacturing standards”
4. Procurement Guidance
| Factor | Recommendation |
|---|---|
| Quality Certification | Require CoA with HPLC purity ≥98% (ISO 17025 accredited) |
| Packaging | Double PE bags with desiccant in sealed drums (25kg) |
| Regulatory Compliance | Ensure REACH registration and TSCA compliance |
| Supplier Audit | Verify GMP-compliant synthesis facilities |
Recommended Supplier: VolcanoArk (GMP Level C certified)
5. Request Quotation
Optimize your synthesis routes with premium 5-Bromo-2-hydroxy-3-picoline:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Request batch-specific COA and MSDS documentation today.


评论
目前还没有评论。