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4,6-Dichloro-5-methylpyrimidine: Comprehensive User Guide
Table of Contents
1. Product Overview and Specifications
4,6-Dichloro-5-methylpyrimidine (CAS 36082-49-8) is a halogenated pyrimidine derivative widely used in pharmaceutical and agrochemical synthesis. Key specifications include:
| Parameter | Specification |
|---|---|
| Molecular Formula | C5H4Cl2N2 |
| Molecular Weight | 163.01 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥98% (HPLC) |
| Storage | 2-8°C in airtight container |
Competitive Advantages vs. Similar Compounds
| Compound | Reactivity | Stability | Cost Efficiency |
|---|---|---|---|
| 4,6-Dichloro-5-methylpyrimidine | High | Excellent | $$ |
| 2,4-Dichloropyrimidine | Moderate | Good | $ |
2. Key Applications and Uses
- Pharmaceutical Intermediates: Synthesis of antiviral agents (e.g., HIV protease inhibitors)
- Agrochemicals: Building block for herbicides and fungicides
- Material Science: Precursor for functionalized polymers
- Research & Development: Scaffold for kinase inhibitor studies
3. Step-by-Step Usage Guidelines
- Handling: Use PPE (gloves, goggles) in a fume hood
- Solubility: Dissolve in dichloromethane (DCM) or THF at 20-25°C
- Reaction Conditions: Typical nucleophilic substitution at 60-80°C under N2
- Workup: Quench with ice-water, extract with DCM, dry over Na2SO4
4. Real-World Case Studies
Case 1: Antiviral Drug Intermediate Synthesis
A European pharma company achieved 92% yield in a Suzuki-Miyaura coupling using 4,6-Dichloro-5-methylpyrimidine as the central scaffold, reducing production costs by 18%.
5. Customer Success Stories
| Customer | Industry | Challenge | Solution | Result |
|---|---|---|---|---|
| ABC Pharma | Biopharma | Low yield in kinase inhibitor synthesis | Optimized substitution protocol | Yield increased from 68% → 85% |
| XYZ Agro | Agrochemicals | Impurity control in herbicide production | Improved purification workflow | Purity ≥99.5% achieved |
6. Request a Quote or Sample
Contact our technical team for customized solutions:
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