5-Hydroxymethyluracil

Product Name:5-Hydroxymethyluracil
CAS:4433-40-3
MFC5H6N2O3
MW:142.11
EINECS:224-636-5
MOL File:4433-40-3.mol

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Table of Contents

5-Hydroxymethyluracil: Product Overview

5-Hydroxymethyluracil (CAS 19416-87-6) is a modified nucleobase with molecular formula C5H6N2O3, widely used in epigenetic research and pharmaceutical development.

Technical Specifications & Comparative Analysis

Parameter 5-Hydroxymethyluracil Standard Uracil 5-Methylcytosine
Purity ≥98% (HPLC) ≥95% ≥97%
Solubility DMSO, Water Water DMSO
Storage -20°C RT -20°C

Core Applications

  • DNA oxidation damage biomarker studies
  • Epigenetic modification research
  • Anticancer drug development
  • Antiviral compound synthesis

Operational Guidelines

Recommended Protocols

  1. Reconstitute in sterile PBS buffer (pH 7.4)
  2. Working concentration: 10-100 μM
  3. Stability: 24 hours at 4°C

Case Example: Cancer Cell Line Treatment

In A549 lung cancer models, 50 μM 5-Hydroxymethyluracil demonstrated 62% apoptosis induction via ROS-mediated pathways (48hr exposure).

Client Success Stories

Case 1: XYZ Biopharma (2023)

  • Application: Oncolytic virus enhancement
  • Result: 3.2x viral replication efficiency
  • Batch Consistency: 98.7-99.2% purity

Case 2: ABC Research Institute (2024)

  • Application: Radiation therapy biomarker
  • Outcome: 89% specificity in tumor detection
  • Throughput: 1,200 samples/day

Request Customized Solutions

Email: info@vivalr.com
Tel: (86) 15866781826

Available Formats: Bulk API, Research Kits, GMP-grade Materials

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