3,5-Dibromo-4-methylpyridine: Technical Guide
Table of Contents
1. Basic Information & Specifications
| Parameter | Value |
|---|---|
| CAS Number | 3430-23-7 |
| Molecular Formula | C6H5Br2N |
| Molecular Weight | 250.919 g/mol |
| Appearance | White crystalline solid |
| Melting Point | 104–107°C |
| Boiling Point | 243.0 ± 35.0°C (at 760 mmHg) |
| Density | 1.9 ± 0.1 g/cm3 |
| Flash Point | 100.7 ± 25.9°C |
| Solubility | Low solubility in water |
2. Key Applications
3,5-Dibromo-4-methylpyridine serves as a versatile intermediate in:
- Pharmaceutical Synthesis: Building block for drug candidates targeting neurological and oncological pathways.
- Agrochemical Development: Precursor for herbicides and fungicides with enhanced selectivity.
- Material Science: Functional component in liquid crystals and electronic materials.
- Research Reagents: Used in cross-coupling reactions (e.g., Suzuki-Miyaura) for heterocyclic compound synthesis.
3. Synthesis Methods
The compound is typically synthesized through:
- Direct Bromination: Controlled bromination of 4-methylpyridine using bromine or NBS (N-bromosuccinimide) under inert conditions.
- Stepwise Functionalization: Sequential halogenation at positions 3 and 5 with purification via recrystallization (common solvents: ethanol/water mixtures).
Typical yields range from 50–65%, with purity >98% achievable through column chromatography.
4. Safety & Handling
- Hazards: Irritant to eyes/skin. Avoid dust inhalation.
- Storage: Keep in airtight containers at 2–8°C under nitrogen.
- PPE: Use nitrile gloves, safety goggles, and fume hood for handling.
- Disposal: Follow local regulations for halogenated organic waste.
5. Regulatory & Trade Information
| Region | HS Code | Regulatory Status |
|---|---|---|
| USA | 2933.39.9100 | Non-hazardous for transport (UN proper shipping name not regulated) |
| EU | 2933.39.90 | REACH registered |
6. Contact for Custom Solutions
For technical specifications, bulk pricing, or custom synthesis projects:
- Email: info@vivalr.com
- Tel: (86) 15866781826 (24/7 support)
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