2-Bromo-5-nitropyridine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
2-Bromo-5-nitropyridine (CAS 4487-52-5) is a brominated nitro-substituted pyridine derivative widely used in pharmaceutical, agrochemical, and materials science research. Key specifications include:
| Parameter | Value |
|---|---|
| Molecular Formula | C5H3BrN2O2 |
| Molecular Weight | 218.99 g/mol |
| Appearance | Yellow crystalline powder |
| Purity | ≥98% (HPLC) |
| Storage | 2-8°C in airtight container |
2. Applications & Use Cases
2-Bromo-5-nitropyridine serves as a versatile intermediate in organic synthesis:
- Pharmaceuticals: Key building block for kinase inhibitors and antiviral agents.
- Agrochemicals: Synthesis of herbicides and fungicides.
- Materials Science: Precursor for OLED materials and conductive polymers.
Typical Reaction Workflow
- Suzuki-Miyaura coupling with boronic acids
- Nucleophilic aromatic substitution
- Catalytic reduction of nitro group
3. Comparative Analysis
| Compound | Reactivity | Cost Efficiency | Stability |
|---|---|---|---|
| 2-Bromo-5-nitropyridine | High (Br activates position 2) | $$ | Stable under inert atmosphere |
| 2-Chloro-5-nitropyridine | Moderate | $ | Sensitive to hydrolysis |
| 5-Nitro-2-iodopyridine | Very High | $$$ | Light-sensitive |
4. Customer Case Studies
Case 1: ABC Pharmaceuticals
Application: Synthesis of JAK3 inhibitor candidate
Scale: 15 kg batch
Result: Achieved 92% yield in Buchwald-Hartwig amination
Case 2: XYZ Agrochemicals
Application: Development of broad-spectrum fungicide
Process: Selective displacement of bromide with thiol group
Outcome: Reduced phytotoxicity vs. chloro analog
5. Request a Quote
Contact our technical team for bulk pricing, SDS, or custom synthesis inquiries:
Email: info@vivalr.com
Phone: (86) 15866781826
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9. Real-world application scenarios
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