2-Cyano-5-fluoropyridine

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Comprehensive Guide to 2-Cyano-5-fluoropyridine

Table of Contents

1. Product Overview

2-Cyano-5-fluoropyridine (CAS 374633-01-9) is a fluorinated pyridine derivative widely used in pharmaceuticals, agrochemicals, and material science. Key specifications include:

Parameter Value
Molecular Formula C6H3FN2
Molecular Weight 138.11 g/mol
Purity ≥98% (HPLC)
Appearance White to off-white crystalline powder
Melting Point 72-75°C
Storage 2-8°C in airtight container

2. Parameter Comparison

Compound Melting Point Reactivity Typical Purity
2-Cyano-5-fluoropyridine 72-75°C High (CN/F groups) ≥98%
2-Cyano-3-fluoropyridine 68-70°C Moderate ≥95%
5-Fluoro-2-methylpyridine N/A (liquid) Low ≥90%

3. Key Applications

Pharmaceutical Intermediates

Used in synthesis of kinase inhibitors, antiviral agents, and CNS drugs due to its electron-withdrawing groups.

Agrochemicals

Key component in next-gen herbicides and fungicides requiring fluorine-enhanced bioavailability.

Material Science

Building block for liquid crystals and conductive polymers in OLED displays.

4. Usage Cases

Case 1: Anticancer Drug Synthesis

Step 1: React with boronic acid under Suzuki conditions
Step 2: Catalytic hydrogenation of nitrile group
Yield: 82% over two steps

Case 2: Herbicide Formulation

10% concentration in non-systemic herbicides showed 94% weed suppression in field trials.

5. Client Case Studies

PharmaTech Solutions (Germany)

Challenge: Required high-purity fluoropyridine derivative for Phase III clinical trial materials
Solution: Supplied 50kg batches at 99.2% purity
Result: Accelerated API production by 6 weeks

AgroChem Solutions (USA)

Challenge: Needed cost-effective fluorinated building block for new herbicide line
Solution: Custom synthesis at 1/3 market price
Result: Launched product 4 months ahead of schedule

6. Request a Quote

Contact our technical team for pricing, COA, or custom synthesis requirements:

Email: info@vivalr.com
Phone: (86) 15866781826

Response within 2 working hours

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