2-Fluoro-4-iodo-5-picoline: Technical Guide & Applications
Table of Contents
1. Product Overview & Specifications
2-Fluoro-4-iodo-5-picoline (CAS 1268805-59-2) is a halogenated pyridine derivative with the molecular formula C6H5F1I1N. Key parameters:
| Parameter | Specification |
|---|---|
| Molecular Weight | 237.02 g/mol |
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white crystalline powder |
| Storage | 2-8°C in inert atmosphere |
2. Applications & Use Cases
Pharmaceutical Intermediates
Widely used in Suzuki-Miyaura cross-coupling reactions for:
- Kinase inhibitor development
- PET radiopharmaceutical precursors
- Anticancer drug candidates
Agrochemical Synthesis
Key building block for:
- Herbicidal compounds
- Fungicide derivatives
- Neonicotinoid analogs
3. Comparative Analysis
| Parameter | 2-Fluoro-4-iodo-5-picoline | 4-Iodo-5-picoline | 2-Chloro-5-picoline |
|---|---|---|---|
| Reactivity | High (F/I synergy) | Moderate | Low |
| Stability | 12 months | 6 months | 9 months |
| Cross-Coupling Yield | 92-95% | 78-82% | 65-70% |
4. Customer Case Studies
Case 1: Oncology Drug Development
Client: Top 10 Pharma Company (Confidential)
Application: Synthesis of FGFR kinase inhibitor
Result: 40% improvement in reaction efficiency vs. previous intermediates
Case 2: OLED Material Production
Client: Material Science Innovator Corp
Application: Electron-transport layer precursor
Result: Achieved 15% higher luminescence efficiency
5. Contact for Custom Solutions
Request technical documentation or bulk quotes:
+86 15866781826
✉️ Custom synthesis available (GMP & non-GMP)
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