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2-Fluoro-4-iodo-5-picoline: Technical Guide & Applications

Table of Contents

1. Product Overview & Specifications

2-Fluoro-4-iodo-5-picoline (CAS 1268805-59-2) is a halogenated pyridine derivative with the molecular formula C6H5F1I1N. Key parameters:

Parameter Specification
Molecular Weight 237.02 g/mol
Purity ≥98% (HPLC)
Appearance White to off-white crystalline powder
Storage 2-8°C in inert atmosphere

2. Applications & Use Cases

Pharmaceutical Intermediates

Widely used in Suzuki-Miyaura cross-coupling reactions for:

  • Kinase inhibitor development
  • PET radiopharmaceutical precursors
  • Anticancer drug candidates

Agrochemical Synthesis

Key building block for:

  • Herbicidal compounds
  • Fungicide derivatives
  • Neonicotinoid analogs

3. Comparative Analysis

Parameter 2-Fluoro-4-iodo-5-picoline 4-Iodo-5-picoline 2-Chloro-5-picoline
Reactivity High (F/I synergy) Moderate Low
Stability 12 months 6 months 9 months
Cross-Coupling Yield 92-95% 78-82% 65-70%

4. Customer Case Studies

Case 1: Oncology Drug Development

Client: Top 10 Pharma Company (Confidential)

Application: Synthesis of FGFR kinase inhibitor

Result: 40% improvement in reaction efficiency vs. previous intermediates

Case 2: OLED Material Production

Client: Material Science Innovator Corp

Application: Electron-transport layer precursor

Result: Achieved 15% higher luminescence efficiency

5. Contact for Custom Solutions

Request technical documentation or bulk quotes:

info@vivalr.com

+86 15866781826

✉️ Custom synthesis available (GMP & non-GMP)

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

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Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

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