2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine: Technical Guide & Applications
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine | 2,4,7-Trichloro Analog | Methoxy Derivative |
|---|---|---|---|
| CAS Number | 129872-82-8 | 1923177-10-9 | 84538-40-9 |
| Molecular Formula | C8H7N3Cl2 | C6H2Cl3N3 | C8H9N3O2 |
| Molecular Weight | 216.07 g/mol | 222.46 g/mol | 179.18 g/mol |
| Purity | ≥95% | Research grade | Lab-grade |
| Typical Packaging | 1g vials | Custom batches | 100mg-5g |
Key Differentiator: Optimized halogen substitution pattern enhances reactivity in nucleophilic aromatic substitution reactions vs. methoxy/methyl derivatives.
2. Key Applications & Industrial Uses
Pharmaceutical Development
- Core scaffold for kinase inhibitors (EGFR, VEGFR)
- Intermediate in antiviral prodrug synthesis
Agrochemical Research
- Precursor for herbicidal heterocyclic compounds
Material Science
- Building block for conductive polymer dopants
3. Operational Use Cases
Case A: Kinase Inhibitor Optimization
Used in Suzuki-Miyaura cross-coupling to introduce aryl groups at 4-position, achieving 78% yield under Pd(PPh3)4 catalysis.
Case B: Scale-up Production
Batch process developed for 5kg-scale synthesis with ≤3% impurities (HPLC).
4. Client Success Stories
Shanghai Biopharma Co., Ltd.
Integrated into EGFR inhibitor R&D pipeline, reduced lead optimization cycle by 40%.
Beijing Solaibao Technology
Custom synthesis of 2,4,7-trichloro derivative for agrochemical applications (500g/mo contract).
5. Request Customized Solutions
Available in R&D to bulk quantities (1g – 50kg).
Contact our technical team:
- Email: info@vivalr.com
- Tel: (86) 15866781826
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