7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
CAS Number: 23782-14-1
Molecular Formula: C6H5N3O2
Purity: ≥98% (HPLC)
Parameter | 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol | Similar Compounds |
---|---|---|
Solubility | DMSO, Methanol | Limited in polar solvents |
Stability | Stable at -20°C | Requires -80°C storage |
Synthetic Complexity | 3-step synthesis | 5-7 steps |
2. Applications & Use Cases
Pharmaceutical Research
Key intermediate for kinase inhibitors (e.g., JAK2/STAT3 pathway modulators). Demonstrated efficacy in oncology preclinical studies.
Organic Synthesis
- Building block for fused heterocyclic systems
- Cross-coupling reactions with palladium catalysts
3. Detailed Usage Scenarios
Example 1: Antiviral Drug Development
Step 1: Dissolve 100 mg in 10 mL DMSO
Step 2: Perform nucleophilic substitution at C-5 position
Yield: 82% after purification
4. Customer Case Studies
Case 1: ABC Pharma (Shanghai)
Challenge: Needed scalable synthesis of BTK inhibitor intermediates
Solution: Optimized 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol coupling protocol
Result: Reduced production costs by 40%
Case 2: XYZ Biotech (Boston)
Challenge: Low yields in fluorinated analog synthesis
Solution: Modified protection-deprotection strategy
Result: Achieved 92% purity in final API
5. Request a Quote
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