Thiobarbituric Acid (TBA) Comprehensive User Guide

Table of Contents

Product Specifications & Comparative Analysis

Parameter Thiobarbituric Acid (TBA) Barbituric Acid
CAS Number 504-17-6 67-52-7
Molecular Formula C4H4N2O2S C4H4N2O3
Molecular Weight 144.15 g/mol 128.09 g/mol
Appearance White crystalline powder White crystals
Key Differentiator Sulfur atom enables lipid peroxidation detection Lacks thiocarbonyl group

Core Industrial & Research Applications

1. Lipid Peroxidation Analysis

Primary use in TBA Reactive Substances (TBARS) assay for measuring oxidative rancidity in:

  • Food quality control (meat, oils, dairy)
  • Biomedical research (oxidative stress biomarkers)
  • Pharmaceutical stability testing

2. Organic Synthesis

  • Building block for heterocyclic compounds
  • Coordination chemistry applications
  • Polymer modification agent

3. Material Science

  • Precursor for sulfur-containing nanomaterials
  • Crosslinking agent in specialty polymers

Implementation Scenarios

Food Industry Application

Challenge: Quantifying malondialdehyde (MDA) levels in processed meats
Solution: TBARS assay with 0.02% TBA solution
Outcome: 94% correlation with sensory evaluation results

Medical Research Application

Challenge: Monitoring oxidative stress in neurodegenerative studies
Solution: TBA-based fluorescence detection (λex 532nm/λem 553nm)
Outcome: Detection limit reduced to 0.1μM MDA equivalents

Verified Client Implementations

Case 1: Food Safety Laboratory

Client: EuroFood Analytics GmbH (Hamburg, Germany)
Challenge: Shelf-life prediction for cured meat products
Implementation: Weekly TBARS monitoring protocol
Result: 22% reduction in product returns due to oxidation

Case 2: Pharmaceutical Research

Client: NovoSynth Biotech (Shanghai, China)
Challenge: Quantifying API degradation during stability trials
Implementation: Modified TBA-HPLC method (USP <1072> compliance)
Result: Achieved 0.99 method linearity (r²) across 3 logs

Technical Consultation & Ordering

Request product specifications or application support:

Available product configurations:

Purity Packaging Price Range
≥98% (ACS grade) 25g glass bottle $45-65
≥99% (HPLC grade) 100g amber vial $150-180
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