2-Chloro-5-methylpyrimidine: Technical Guide for Industrial Applications
Table of Contents
1. Product Overview & Specifications
| Parameter | 2-Chloro-5-methylpyrimidine | Comparable Compounds |
|---|---|---|
| CAS Number | 22536-61-4 | 33252-28-7 (2-Chloro-5-cyanopyridine) |
| Molecular Formula | C5H5N2Cl | C6H3ClN2 |
| Appearance | Light-yellow liquid | Crystalline solid |
| Density | 1.169 g/mL (25°C) | 1.33 g/cm³ |
| Boiling Point | 97°C (30 mmHg) | 236.4°C |
| Flash Point | 195°F (90.6°C) | 96.8°C |
2. Key Applications
This compound serves as a critical intermediate in:
- Agrochemical synthesis (neonicotinoid insecticides)
- Pharmaceutical manufacturing (API intermediates)
- Specialty chemical production (functionalized pyrimidines)
3. Usage Guidelines
Handling Precautions
- Use PPE including chemical goggles and nitrile gloves
- Store in sealed containers under inert atmosphere
- Maintain temperature below 25°C in well-ventilated areas
Reaction Compatibility
- Effective in nucleophilic substitution reactions
- Compatible with Grignard reagents at controlled temperatures
- Stable in acidic media below pH 3
4. Industry Case Studies
Case 1: Insecticide Manufacturing
A Jiangsu-based agrochemical producer achieved 18% yield improvement in imidacloprid synthesis by optimizing chlorination parameters using 2-Chloro-5-methylpyrimidine as a key intermediate.
Case 2: Pharmaceutical Intermediate
Shanghai Ruihui Chemical successfully scaled up production of antiviral drug candidates through regioselective functionalization of 2-Chloro-5-methylpyrimidine under GMP conditions.
5. Contact Information
For technical specifications or bulk inquiries:
Email: info@vivalr.com
Phone: (86) 15866781826
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