2-Fluoro-4-methyl-5-nitropyridine

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2-Fluoro-4-methyl-5-nitropyridine: Technical Guide & Industry Applications

Contents

Product Overview

Parameter Specification
CAS Number 1072-14-0
Molecular Formula C6H5FN2O2
Purity ≥98% (HPLC)
Appearance Yellow crystalline powder
Storage Conditions 2-8°C in airtight container

Comparative Analysis

Derivative Fluorine Position Reactivity Typical Yield
2-Fluoro-4-methyl-5-nitropyridine Ortho High 85-92%
3-Fluoro-5-nitropyridine Meta Moderate 72-78%

Industrial Applications

Pharmaceutical Intermediates

Critical component in synthesis of:

  • Kinase inhibitor precursors
  • Anticancer drug candidates
  • Antiviral compound backbones

Agrochemical Development

Essential for creating:

  • Next-gen pesticide formulations
  • Herbicide metabolites
  • Fungicide active ingredients

Operational Protocols

Laboratory Handling

  1. Use dry nitrogen atmosphere for sensitive reactions
  2. Maintain reaction temperature below -10°C for nitro group stability
  3. Employ Pd/C catalyst for hydrogenation steps

Industrial Scale Processing

  1. Implement continuous flow reactors for nitration steps
  2. Monitor exothermic reactions with RTD sensors
  3. Utilze cryogenic distillation for purification

Client Success Stories

Case 1: Oncology Research Institute

  • Challenge: Low yield in kinase inhibitor synthesis
  • Solution: Optimized fluoropyridine coupling conditions
  • Result: 40% yield improvement

Case 2: Agrochemical Manufacturer

  • Challenge: Unstable intermediate in pesticide production
  • Solution: Modified nitro group protection strategy
  • Result: 99.5% intermediate stability achieved

Request Customized Solutions

Contact our technical team for:

  • Bulk pricing (100kg+ quantities)
  • Custom fluorination services
  • GMP-grade production options

Email: info@vivalr.com
Phone: (86) 15866781826

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