6-Hydroxy-5-nitronicotinic acid

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Table of Contents

1. Product Overview & Specifications

Chemical Profile

Parameter Specification
Chemical Name 6-Hydroxy-5-nitronicotinic acid
CAS Number 403618-50-8
Molecular Formula C6H4N2O5
Molecular Weight 200.11 g/mol
Appearance Yellow crystalline powder
Purity ≥98% (HPLC)
Storage Conditions 2-8°C in dark containers

Comparative Analysis

Feature Our Product Industry Standard
Purity Level 98-99.5% 95-97%
Thermal Stability Stable up to 150°C Decomposes at 130°C
Solubility DMSO >50mg/ml DMSO 30-40mg/ml

2. Key Applications & Industrial Uses

Pharmaceutical Intermediates

Essential for synthesizing novel kinase inhibitors in oncology research, particularly in:

  • EGFR tyrosine kinase inhibitors development
  • Anti-inflammatory drug precursors
  • Neurological disorder treatment candidates

Organic Synthesis

  • Building block for complex heterocyclic compounds
  • Coordination chemistry applications
  • Photovoltaic material synthesis

3. Usage Guidelines & Best Practices

Handling Protocols

  1. Always use nitrogen atmosphere for sensitive reactions
  2. Recommended solvent: anhydrous DMF/DMSO
  3. Optimal reaction temperature: 60-80°C

Safety Considerations

  • Use explosion-proof equipment for large-scale reactions
  • Implement secondary containment for nitro group handling

4. Implementation Case Studies

Case 1: Pharmaceutical Intermediate Production

Challenge: Required high-purity intermediate for GMP-compliant API synthesis
Solution: Custom purification process achieving 99.2% purity
Outcome: 30% yield improvement vs traditional methods

Case 2: Advanced Material Development

Challenge: Creating thermally stable coordination polymers
Solution: Optimized molar ratio (1:1.2) with transition metals
Outcome: Achieved 148°C thermal stability threshold

5. Verified Client Success Stories

Client A: Top-10 Pharma Company

Project: Development of third-generation EGFR inhibitors
Usage: 15kg over 18-month R&D cycle
Result: Accelerated IND submission by 5 months

Client B: Specialty Chemicals Manufacturer

Project: High-performance corrosion inhibitors
Usage: Batch production of 200kg/month
Result: 40% improvement in product lifespan

6. Technical Consultation & Quotation

For customized formulations or bulk inquiries:
Email: info@vivalr.com
Phone: (86) 15866781826
Our experts provide:
– Technical data package (TDP)
– Regulatory support documentation
– Custom synthesis feasibility studies

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