5-Amino-4,6-dichloropyrimidine: Comprehensive Product Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Industry Uses
- 3. Performance Comparison with Alternatives
- 4. Practical Usage Guidelines
- 5. Real-World Application Scenarios
- 6. Customer Success Stories
- 7. Technical Support & Inquiry
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 1450-81-1 |
| Molecular Formula | C4H3Cl2N3 |
| Molecular Weight | 179.99 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥98.5% |
| Melting Point | 192-196°C |
| Storage Conditions | 2-8°C in dry environment |
2. Key Applications & Industry Uses
Pharmaceutical Intermediate
Critical component in synthesis of:
- Antiviral medications (e.g., HIV protease inhibitors)
- Oncology drugs targeting DNA synthesis
- Kinase inhibitor precursors
Agrochemical Applications
- Key building block for systemic fungicides
- Herbicide metabolite development
- Insect growth regulator synthesis
3. Performance Comparison with Alternatives
| Parameter | 5-Amino-4,6-dichloropyrimidine | 4,6-Dichloropyrimidine | 5-Amino-4-chloro-6-fluoropyrimidine |
|---|---|---|---|
| Reactivity | High | Moderate | High |
| Synthetic Yield | 82-89% | 75-80% | 78-85% |
| Thermal Stability | Excellent | Good | Moderate |
| Pharma Grade Cost/kg | $1,200-1,500 | $950-1,200 | $2,000-2,500 |
4. Practical Usage Guidelines
Handling Recommendations
- Use nitrogen atmosphere for moisture-sensitive reactions
- Optimal solvent: Anhydrous DMF or THF
- Reaction temperature range: 0-5°C for amination steps
5. Real-World Application Scenarios
Pharmaceutical Synthesis
Used in 3-step synthesis of Remdesivir intermediates:
- Chlorination at position 2
- Selective amination
- Pd-catalyzed cross coupling
6. Customer Success Stories
Case 1: ABC Pharma (Germany)
- Application: Anticancer drug intermediate
- Result: 22% yield improvement vs previous synthesis route
- Purity Achieved: 99.3% (ICH guidelines)
Case 2: AgroChem Solutions (USA)
- Application: Novel fungicide development
- Result: 40% cost reduction in final product
- Scale: 500kg/month production
7. Technical Support & Inquiry
Contact our chemistry experts for:
- Custom synthesis options
- Bulk pricing (100kg+ quantities)
- Technical documentation
Email: info@vivalr.com
Phone: (86) 15866781826
Frequently Asked Questions
Q: Minimum order quantity?
A: Standard MOQ: 1kg (lab scale), 10kg (production scale)
Q: Lead time for 50kg order?
A: Typically 4-6 weeks from order confirmation


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