3-Amino-2-chloro-6-(trifluoromethyl)pyridine

Table of Contents

• 1. Product Overview
• 2. Key Applications
• 3. Parameter Comparison
• 4. Usage Guidelines
• 5. Case Studies
• 6. Request Quotation

1. Product Overview

3-Amino-2-chloro-6-(trifluoromethyl)pyridine (CAS 37439-34-2)

Molecular Formula: C6H4ClF3N2

Molecular Weight: 196.5 g/mol

Structural Features: Chlorine substituent at position 2, amino group at position 3, and trifluoromethyl group at position 6 on pyridine ring

Technical Specifications

2. Key Applications

Pharmaceutical Intermediate

Critical building block for kinase inhibitors and CNS drugs with enhanced blood-brain barrier penetration capabilities.

Agrochemical Synthesis

Key component in next-generation pesticides demonstrating 85% higher pest resistance compared to traditional chloropyridine derivatives.

Material Science

Precursor for electronic materials with low dielectric constant (k=2.3) and high thermal stability (up to 300°C).

3. Parameter Comparison

4. Usage Guidelines

Handling Recommendations

• Use nitrogen-purged environment for sensitive reactions
• Optimal reaction temperature: -10°C to 40°C
• Recommended solvent: anhydrous DMF or THF

Safety Protocols

• GHS Classification: H302-H315-H319-H335
• PPE Requirements: Chemically resistant gloves + full-face respirator
• Spill Management: Absorb with inert material and dispose as hazardous waste

5. Case Studies

Case 1: Oncology Drug Development

Client: Top 10 Pharma Company (Confidential)

Application: Synthesized 23 novel EGFR inhibitors using this intermediate

Result: 3 candidates showed IC50 values <10nM in preclinical trials

Case 2: Agricultural Formulation

Client: European Agrochemical Producer

Application: Developed systemic insecticide with 92% efficacy against resistant aphid strains

Result: Reduced application frequency by 40% compared to market alternatives

Case 3: Electronic Materials

Client: OLED Manufacturer

Application: Created electron-transport layer with 15% improved luminescence efficiency

Result: Achieved 100,000hr operational lifespan at 1000cd/m² brightness

6. Request Quotation

Contact our technical team for:

• Custom synthesis services (gram to kilogram scale)
• Regulatory support (REACH, TSCA compliance)
• Technical documentation (CoA, MSDS, CMC packages)

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