3-Amino-2-bromopyridine

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3-Amino-2-bromopyridine: Technical Guide & Applications

1. Product Overview & Specifications

Parameter 3-Amino-2-bromopyridine Similar Compounds
CAS Number 39856-58-1 13534-99-1 (isomer)
Molecular Formula C5H5BrN2 C5H5ClN2
Molecular Weight 173.01 g/mol 174.02 g/mol
Melting Point 74-79°C 68-72°C
Flash Point 130.7°C 128°C

This brominated pyridine derivative exhibits superior thermal stability compared to chlorinated analogs, with a vapor pressure of 0.00182 mmHg at 25°C.

2. Key Applications

Pharmaceutical Intermediates

  • Core building block for kinase inhibitors
  • Precursor in anticancer drug synthesis

Agrochemical Development

  • Key component in pesticide formulations
  • Herbicide synergy agent

Material Science

  • Ligand in coordination polymers
  • Crosslinking agent for specialty resins

3. Usage Guidelines

Handling Protocols

  • Storage: 2-8°C under inert atmosphere
  • PPE Requirements: Nitrile gloves, chemical goggles

Reaction Optimization

  • Ideal coupling conditions: Pd(PPh3)4 catalyst
  • Optimal solvent systems: THF/DMF mixtures

4. Industry Case Studies

Case 1: Oncology Drug Development

Used in multi-step synthesis of Bruton’s tyrosine kinase (BTK) inhibitors, achieving 92% yield in Buchwald-Hartwig amination.

Case 2: Crop Protection Formulation

Enhanced fungicidal activity by 40% in triazole derivatives through strategic bromine positioning.

5. Client Success Stories

PharmaTech Solutions (Shanghai)

  • Application: PARP inhibitor development
  • Result: Reduced side reactions by 65%
  • Scale: 200kg/month production

AgroNova Ltd. (Guangzhou)

  • Application: Systemic fungicide enhancement
  • Result: Extended residual activity by 3 weeks
  • Scale: 500kg batch processing

6. Contact for Custom Solutions

Request technical specifications or discuss bulk pricing:

Contact Method Details
Email info@vivalr.com
Phone (86) 15866781826
Lead Time 3-5 business days for samples

Our technical team provides:

  • HPLC purity certificates
  • Custom synthesis protocols
  • Regulatory support documentation

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