5-Bromo-2,4-dichloropyrimidine: Comprehensive Product Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Industry Use Cases
- 3. Technical Comparison with Analogues
- 4. Operational Guidelines & Safety Protocols
- 5. Client Success Stories
- 6. Request Customized Solutions
1. Product Overview & Specifications
CAS Number: 16059-36-6
Molecular Formula: C4BrCl2N2
Molecular Weight: 242.83 g/mol
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥98% |
| Melting Point | 89-93°C |
| Storage Conditions | 2-8°C in inert atmosphere |
2. Key Applications & Industry Use Cases
Pharmaceutical Intermediates
Critical building block for antiviral agents like reverse transcriptase inhibitors. Enables precise bromine-chlorine substitution patterns crucial for drug-target binding.
Agrochemical Synthesis
Used in crop protection chemical development, particularly fungicides requiring halogenated pyrimidine cores for bioactivity.
Material Science
Key precursor for electronic materials requiring halogen-doped aromatic systems in OLED and semiconductor applications.
3. Technical Comparison with Analogues
| Compound | Reactivity | Stability | Typical Yield |
|---|---|---|---|
| 5-Bromo-2,4-dichloropyrimidine | High (Buchwald-Hartwig coupling) | Air-sensitive | 82-88% |
| 2,4-Dichloropyrimidine | Moderate | Stable | 75-80% |
| 5-Iodo-2,4-dichloropyrimidine | Very High | Light-sensitive | 65-72% |
4. Operational Guidelines & Safety Protocols
Handling Procedures
• Always use glove boxes under nitrogen atmosphere for weighing
• Quench reactions with 10% sodium thiosulfate solution
Solubility Data
• DCM: 50 mg/mL
• THF: 32 mg/mL
• Water: <1 mg/mL
5. Client Success Stories
Case 1: Antiviral Drug Development
Client: Top 10 Global Pharma Company
Application: Synthesis of NNRTI candidate (Phase II)
Result: Achieved 92% coupling efficiency vs. 78% with alternative reagents
Case 2: Advanced Material Research
Client: OLED Materials Innovator
Application: Electron transport layer component
Result: Enhanced device lifetime by 40% compared to standard materials
6. Request Customized Solutions
Our technical team provides:
- Bulk synthesis up to 100kg scale
- Custom halogenation patterns
- GMP-grade production
Contact our experts:
Email: info@vivalr.com
Phone: (86) 15866781826


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