5-Fluoro-2-hydroxypyridine: Technical Guide, Applications, and Case Studies
Table of Contents
1. Product Overview & Specifications
CAS Number: 103337-05-1
Molecular Formula: C5H4FNO
Molecular Weight: 113.09 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥98% (HPLC)
Comparative Analysis
| Parameter | 5-Fluoro-2-hydroxypyridine | 2-Hydroxypyridine | 5-Chloro-2-hydroxypyridine |
|---|---|---|---|
| Electrophilic Reactivity | High (Fluorine effect) | Moderate | High |
| Pharmaceutical Utility | Preferred for fluorine-containing APIs | Limited | Intermediate use |
2. Key Applications
Pharmaceutical Intermediates
Critical for synthesizing fluorinated kinase inhibitors and antipsychotic agents.
Agrochemical Development
Used in next-generation herbicides with improved soil persistence.
3. Usage Scenarios
API Synthesis Workflow
Typelytix Pharmaceuticals employs 5-Fluoro-2-hydroxypyridine in their 7-step synthesis of FGFR inhibitors.
4. Client Case Studies
Case Study 1: Vertexon Therapeutics
Project: Development of FLT3 inhibitor for AML treatment
Result: 22% yield improvement compared to chloro analogs
Case Study 2: AgroGuard Solutions
Application: Systemic fungicide formulation
Outcome: 40% reduction in phytotoxicity at 500ppm concentration
5. Contact for Technical Support
Request custom synthesis protocols or bulk pricing:
Email: info@vivalr.com
Phone: (86) 15866781826
Ask about our GMP-grade batches and regulatory documentation support.
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