3-Chloro-4-Methylpyridine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
3-Chloro-4-Methylpyridine (CAS 5400-22-8) is a heterocyclic organic compound widely used in pharmaceuticals, agrochemicals, and organic synthesis. Key parameters:
| Parameter | Value |
|---|---|
| Molecular Formula | C6H6ClN |
| Molecular Weight | 127.57 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Purity | ≥98% (GC) |
| Melting Point | -15°C to -10°C |
| Boiling Point | 210-212°C |
Competitive Comparison
| Feature | 3-Chloro-4-Methylpyridine | 4-Chloro-3-Methylpyridine |
|---|---|---|
| Reactivity | Higher electrophilicity | Moderate |
| Pharma Applications | Preferred for antihistamines | Limited use |
2. Applications of 3-Chloro-4-Methylpyridine
Pharmaceutical Intermediate
Key building block for:
- Antihistamine APIs (e.g., Loratadine derivatives)
- Non-nucleoside reverse transcriptase inhibitors
Agrochemical Synthesis
- Insecticide precursors
- Herbicide synergists
3. Usage Scenarios & Best Practices
Scenario 1: Pharmaceutical GMP Production
Step 1: Purify via vacuum distillation (≤10 mmHg)
Step 2: React with ethyl chloroformate at 0-5°C
Scenario 2: Catalyst Preparation
Coordination with Pd(OAc)2 in ethanol/water (3:1 ratio)
4. Real-World Case Studies
Case Study 1: PharmaHealth Solutions
Challenge: Improve yield of antihistamine intermediate
Solution: Optimized reaction using 3-Chloro-4-Methylpyridine
Result: 22% yield increase, 99.2% purity
Case Study 2: AgroGuard Innovations
Developed low-toxicity insecticide with 40% cost reduction
5. Request a Quote or Technical Support
Contact our chemical experts for:
- Bulk pricing (25kg drums available)
- Custom synthesis options
- MSDS & regulatory support
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