5-FLUORO-8-HYDROXYQUINOLINE

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5-FLUORO-8-HYDROXYQUINOLINE: Comprehensive User Guide

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter 5-Fluoro-8-Hydroxyquinoline 8-Hydroxyquinoline 5-Chloro-8-Hydroxyquinoline
CAS Number 607-24-7 148-24-3 130-16-5
Molecular Formula C9H6FNO C9H7NO C9H6ClNO
Purity Grade ≥98% (HPLC) ≥95% ≥97%
Melting Point 228-232°C 74-76°C 192-194°C

2. Key Applications & Industrial Uses

Pharmaceutical Intermediate: Critical component in synthesizing quinolone antibiotics with enhanced antimicrobial activity against Gram-positive bacteria.

Metal Chelation: Superior binding capacity for transition metals (Cu²⁺, Fe³⁺) compared to non-fluorinated analogs in industrial catalysts.

Analytical Chemistry: Fluorescent probe for aluminum ion detection with detection limit of 0.1 μM in environmental monitoring.

3. Operational Best Practices

Storage: Maintain in amber glass containers at 2-8°C under nitrogen atmosphere to prevent oxidative degradation.

Handling: Use PPE including neoprene gloves and chemical goggles due to potential skin/eye irritation (LD50 oral rat: 320 mg/kg).

Solubility Optimization: Achieve 25 mg/mL in ethanol:water (7:3 v/v) mixtures at 40°C with ultrasonic assistance.

4. Case Studies & Implementations

Case 1: European API manufacturer increased antibiotic yield by 18% through fluorinated quinoline intermediates in ciprofloxacin synthesis.

Case 2: Japanese electronics firm developed novel OLED materials using metal-chelate complexes with 15% improved luminescence efficiency.

5. Client Success Stories

Client A: Top 10 Pharma Company (USA) reduced synthetic steps from 7 to 4 in new antibacterial drug development using our GMP-grade material.

Client B: German Research Institute created advanced wastewater treatment system with 99.2% heavy metal removal efficiency.

Client C: Asian Agrochemical Leader developed next-gen fungicide with 40% lower application rates through fluorinated active components.

6. Request Customized Solutions

Contact our technical team for:

  • Bulk pricing (100kg+ orders)
  • Custom synthesis (purity 98-99.9%)
  • Regulatory support (REACH, FDA DMF)

Email: info@vivalr.com
Tel: (86) 15866781826

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