2-Chloro-3-fluoropyridine

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Comprehensive Guide to 2-Chloro-3-fluoropyridine

Table of Contents

1. Product Overview

2-Chloro-3-fluoropyridine (CAS 1480-65-5) is a halogenated pyridine derivative with molecular formula C5H3ClFN. This heterocyclic compound features:

  • Molecular Weight: 131.53 g/mol
  • Appearance: Colorless to pale yellow liquid
  • Boiling Point: 142-144°C at 760 mmHg
  • Density: 1.398 g/cm3 at 25°C

2. Key Specifications & Comparative Analysis

Parameter 2-Chloro-3-fluoropyridine 2-Chloropyridine 3-Fluoropyridine
Reactivity Index 0.78 0.65 0.71
Pharmaceutical Compatibility High Medium Low
Thermal Stability Up to 200°C 180°C 190°C

3. Industrial Applications

3.1 Pharmaceutical Intermediate

Used in synthesizing:

  • Kinase inhibitors (e.g., EGFR inhibitors)
  • Antiviral agents
  • Neuropharmaceuticals

3.2 Agrochemical Production

Key component in:

  • Next-gen herbicides (e.g., Fluroxypyr derivatives)
  • Insect growth regulators

4. Application Case Studies

4.1 Anticancer Drug Development

Used as core structure in third-generation BTK inhibitors showing 89% improved bioavailability compared to previous analogs.

4.2 Electronic Materials

Implemented in OLED electron transport layers, achieving 15% efficiency improvement in prototype displays.

5. Client Success Stories

5.1 European Pharma Leader

“Vivalr’s 2-Chloro-3-fluoropyridine enabled 40% faster synthesis of our lead oncology candidate while maintaining 99.8% purity throughout scale-up.”

5.2 US Agrochemical Innovator

“The compound’s unique reactivity profile helped us develop a breakthrough herbicide with 92% weed control efficacy at half the application rate.”

6. Request Customized Solutions

Our capabilities include:

  • Bulk quantities (100kg+ batches)
  • Custom purity grades (98%-99.9%)
  • Stable isotope-labeled versions

Contact our technical team:
Email: info@vivalr.com
Tel: (86) 15866781826

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