5-CHLORO-2-HYDROXYPYRIMIDINE

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5-CHLORO-2-HYDROXYPYRIMIDINE: Comprehensive Product Guide

Table of Contents

1. Product Overview & Specifications

Parameter Specification
CAS Number 22129-87-7
Molecular Formula C4H3ClN2O
Molecular Weight 130.53 g/mol
Appearance White to off-white crystalline powder
Purity ≥98% (HPLC)
Storage 2-8°C in dry container

Comparative Analysis

Feature 5-Chloro-2-hydroxypyrimidine 2-Hydroxypyrimidine 5-Bromo-2-hydroxypyrimidine
Reactivity High nucleophilic substitution potential Moderate Excellent for coupling reactions
Pharma Applications Antiviral intermediates Limited Oncological compounds

2. Key Applications

This heterocyclic compound serves as:

  • Building block for nucleotide analogs in antiviral drugs
  • Intermediate in agrochemical synthesis (herbicides/pesticides)
  • Ligand precursor in catalytic systems

3. Usage Scenarios

Pharmaceutical Synthesis

Used in 3-step synthesis of Remdesivir analogs through chlorination and glycosylation.

Agrochemical Production

Key intermediate in pyrimidine-containing fungicides with 85-92% yield in coupling reactions.

4. Industry Case Studies

Case 1: Antiviral Drug Development

Client: Top 10 Global Pharma Company
Application: Nucleoside analog synthesis
Result: Achieved 40% faster reaction kinetics vs. bromo derivatives

Case 2: Novel Insecticide Formulation

Client: EU Agrochemical Manufacturer
Application: Chlorinated pyrimidine core structure
Result: 30% cost reduction in production scale-up

5. Request Quotation

Contact our technical team for:

  • Batch-specific COA
  • Custom synthesis options
  • Bulk pricing (25kg+ quantities)

Email: info@vivalr.com
Tel: (86) 15866781826

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