6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLIC ACID

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Comprehensive Guide to 6-Chloroimidazo[1,2-b]pyridazine-2-carboxylic Acid

1. Product Overview and Specifications

6-Chloroimidazo[1,2-b]pyridazine-2-carboxylic Acid (CAS: 1186086-67-4) is a heterocyclic compound widely used in pharmaceutical research and organic synthesis. Below are its key parameters:

Parameter Specification
Molecular Formula C7H4ClN3O2
Molecular Weight 213.58 g/mol
Purity ≥98% (HPLC)
Appearance White to off-white crystalline powder
Storage 2-8°C in airtight containers

Comparative Analysis

Compared to similar intermediates, this compound offers:

  • Higher solubility in polar solvents (e.g., DMSO, DMF)
  • Enhanced stability under acidic conditions
  • Lower toxicity profile (LD50 > 500 mg/kg)

2. Key Applications and Uses

This compound is critical in:

  • Pharmaceutical Synthesis: Intermediate for kinase inhibitors and antiviral agents
  • Agrochemical Research: Building block for herbicidal compounds
  • Material Science: Precursor for conductive polymers

Reaction Compatibility

  • Suzuki-Miyaura cross-coupling
  • Buchwald-Hartwig amination
  • Esterification and amidation reactions

3. Usage Guidelines and Best Practices

Handling Recommendations

  • Use PPE (gloves, goggles) in well-ventilated areas
  • Store away from strong oxidizers
  • Optimal reaction temperature: 20-80°C

Solubility Data

Solvent Solubility (mg/mL)
DMSO 50
Ethanol 8
Water <0.1

4. Case Studies and Client Success Stories

Case Study 1: Antiviral Drug Development

Client: European PharmaCo (2023)

  • Used as a core scaffold in NS5B polymerase inhibitors
  • Resulted in 40% improved bioavailability vs. previous analogs

Case Study 2: Agricultural Chemical Innovation

Client: AgroSolutions Ltd. (2022)

  • Modified to create novel herbicidal agents
  • Achieved 90% weed suppression at 50g/hectare

Case Study 3: Materials Science Breakthrough

Client: NanoTech Materials Inc. (2023)

  • Integrated into π-conjugated polymers
  • Enhanced electrical conductivity by 3x vs. standard materials

5. Inquiry and Contact Information

For technical specifications, bulk orders, or custom synthesis inquiries:

Request a free sample or consult our chemists for application-specific guidance.

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