2-Amino-5-nitro-4-picoline: Technical Guide for Industrial Applications

1. Product Overview & Specifications

Parameter Specification
Chemical Name 2-Amino-5-nitro-4-picoline
CAS Number 21901-40-6
Molecular Formula C6H7N3O2
Molecular Weight 153.14 g/mol
Appearance Yellow crystalline powder
Purity Grade Industrial (≥98%)

2. Key Applications & Functional Properties

Core Applications:

  • Pharmaceutical intermediates for antimalarial drugs
  • Precursor in agrochemical synthesis
  • Dye manufacturing intermediate
  • Coordination chemistry applications

Functional Advantages:

  • High reactivity in nitro-group transformations
  • Thermal stability up to 180°C
  • Solubility in polar aprotic solvents

3. Industrial Use Cases

Case Study 1: Antiparasitic Drug Synthesis

Used as critical intermediate in production of antiparasitic compounds through nucleophilic substitution reactions. Enables 32% yield improvement compared to traditional pathways.

Case Study 2: Specialty Dye Manufacturing

Key component in synthesis of azo dyes for textile industry, providing enhanced color fastness and UV stability in final products.

4. Synthesis & Quality Control

Manufacturing Process:

  1. Nitration of 2-amino-4-picoline precursor
  2. Controlled sulfonation reaction
  3. Multi-stage purification process

QC Parameters:

Test Method Spec
Assay HPLC ≥98%
Residual Solvents GC <500 ppm

5. Safety Protocols & Handling

Hazard Classification:

  • Acute Toxicity (Category 3)
  • Skin Corrosion (Category 1B)

PPE Requirements:

  • Chemical-resistant gloves (Butyl rubber)
  • Full-face respirator with organic vapor cartridge
  • Impervious protective clothing

First Aid Measures:

Exposure Route Response Protocol
Inhalation Immediate removal to fresh air, administer oxygen if needed
Skin Contact Flush with water for 15 minutes, remove contaminated clothing

6. Technical Inquiry Guidance

For customized specifications or bulk pricing:

Request the following when inquiring:

  1. Required quantity (kg/Ton)
  2. Packaging specifications
  3. Target application details
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