2-Hydroxy-4-methylpyrimidine hydrochloride

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Product Overview: 2-Hydroxy-4-methylpyrimidine Hydrochloride

CAS Number: 202409-82-7
Molecular Formula: C5H7N2O·HCl
Molecular Weight: 162.59 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥98% (HPLC)
Solubility: Soluble in water, methanol, and DMSO; slightly soluble in ethanol
Storage: 2-8°C in airtight container

Technical Specifications & Comparative Analysis

Parameter 2-Hydroxy-4-methylpyrimidine HCl 2-Hydroxypyrimidine 4-Methylpyrimidine HCl
Molecular Weight 162.59 112.09 150.59
Aqueous Solubility (25°C) 85 mg/mL 120 mg/mL 45 mg/mL
Melting Point 215-218°C 190-193°C 205-208°C
Pharmaceutical Applications High Moderate Low

Core Applications in Industrial & Research Sectors

1. Pharmaceutical Intermediates

  • Key precursor for kinase inhibitor development
  • Building block for antiviral drug synthesis
  • Intermediate in anticancer compound research

2. Organic Synthesis

  • Coordination chemistry applications
  • Heterocyclic compound modification
  • Metal-organic framework (MOF) development

3. Agrochemical Development

  • Fungicide formulations
  • Herbicide intermediates
  • Plant growth regulators

Operational Protocols & Safety Considerations

  • Recommended handling: Use PPE (gloves, goggles, lab coat)
  • Storage stability: 24 months when stored properly
  • Incompatibilities: Strong oxidizers, alkaline solutions
  • Disposal: Follow local hazardous waste regulations

Documented Industry Applications

Case Study 1: Pharmaceutical API Development

Client: European Pharma Research Consortium
Application: Intermediate for Bruton’s tyrosine kinase (BTK) inhibitor
Result: Achieved 99.2% purity in final API
Scale: 150 kg batch production

Case Study 2: Agricultural Formulation Enhancement

Client: APAC Agrochemical Solutions Ltd.
Application: Systemic fungicide formulation improvement
Result: 40% efficacy increase against Puccinia graminis
Output: Commercialized product in 14 markets

Case Study 3: Advanced Material Synthesis

Client: US University Materials Lab
Application: MOF development for gas storage
Result: Achieved 12% higher CO2 adsorption capacity
Publication: Journal of Materials Chemistry A, 2023

Request Customized Quotation

Contact our technical team for:
– Bulk pricing (100kg+ orders)
– Custom synthesis specifications
– Regulatory documentation support
Email: info@vivalr.com
Tel: (86) 15866781826

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