Cinchonine CAS 118-10-5

Table of Contents

• Cinchonine (CAS 118-10-5) Overview
• Technical Specifications & Comparative Analysis
• Key Applications & Industry Uses
• Pharmaceutical Research Case Study
• Asymmetric Synthesis Application
• Antimalarial Drug Development – ABC Pharma
• Chiral Catalyst Production – XYZ Chemicals
• Request Customized Solutions

Cinchonine (CAS 118-10-5) Overview

Basic Chemical Properties

Technical Specifications & Comparative Analysis

Key Applications & Industry Uses

Pharmaceutical Applications

1. Malaria Treatment Adjuvant: Enhances quinine efficacy through pharmacokinetic modulation
2. Cardiac Research: Modulates ion channels in electrophysiology studies
3. Neurological Studies: GABA receptor interaction analysis

Chemical Synthesis Uses

1. Asymmetric catalysis in chiral molecule synthesis
2. Resolution agent for enantiomeric separation
3. Organocatalyst in Michael addition reactions

Pharmaceutical Research Case Study

Project: Antimalarial Combination Therapy Development

1. Challenge: Reduce quinine dosage while maintaining efficacy
2. Solution: 1:3 cinchonine-quinine co-formulation
3. Result: 40% dosage reduction with equivalent parasite clearance rate
4. Process: In vitro hemozoin inhibition assay → murine model validation

Asymmetric Synthesis Application

Process: Enantioselective Aldol Reaction

1. Substrate: Prochiral ketones
2. Catalyst: Cinchonine-derived thiourea (0.5 mol%)
3. Conditions: Toluene, -20°C, 24h
4. Outcome: 92% yield, 88% ee
5. Scale-up: Successful kilogram-scale production

ABC Pharma – Antimalarial Development

XYZ Chemicals – Catalyst Production

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Technical & Commercial Consultation

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