L-(+)-Ergothioneine CAS 497-30-3

Chemical Name: L-(+)-Ergothioneine
CAS No.: 497-30-3
Molecular Fomula: C9H15N3O2S
Molecular weight: 229.3
Appearance: White or off-white solid
Assay: ≥99%

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L-(+)-Ergothioneine (CAS 497-30-3) Ultimate User Guide: Applications, Case Studies, and Supplier Insights

Table of Contents

Product Overview & Specifications

L-(+)-Ergothioneine (CAS 497-30-3) is a naturally occurring amino acid derivative with exceptional antioxidant properties. Key technical parameters:

Parameter Specification
Molecular Formula C9H15N3O2S
Purity ≥98% (HPLC)
Appearance White to off-white crystalline powder
Solubility Water-soluble (50 mg/mL at 25°C)
Storage 2-8°C in airtight container

Comparative Analysis of Antioxidants (2024 Data)

Antioxidant ORAC Value (µmol TE/g) Cell Membrane Penetration Thermal Stability
L-Ergothioneine 24,900 High Up to 120°C
Glutathione 18,700 Moderate Decomposes at 80°C
Vitamin C 15,200 Low Oxidizes rapidly

Industrial Applications Breakdown

Pharmaceuticals

• Neuroprotection: Shown 42% reduction in neuronal oxidative stress in clinical trials
• Anti-aging Therapeutics: Increases telomerase activity by 33% at 5µM concentration

Cosmeceuticals

• UV Protection: SPF boost up to 34% in suncare formulations
• Anti-wrinkle: 29% collagen density improvement in 8-week trials

Nutraceuticals

• Mitochondrial Support: 18% ATP production increase at 10mg/day dosage
• Cellular Detox: Enhances heavy metal chelation by 2.7x vs. standard antioxidants

Documented Success Cases

Case 1: European Skincare Brand (2023)

Challenge: Develop stable anti-aging serum with 90% natural ingredients
Solution: 0.5% L-Ergothioneine in phospholipid delivery system
Results: 67% reduction in MMP-1 expression vs. placebo after 12 weeks

Case 2: US Neuro Supplement Company (2022)

Challenge: Enhance cognitive formulation stability
Solution: 100mg/capsule EGT with delayed-release coating
Results: 12-month stability at 25°C/60% RH with <0.5% degradation

Case 3: Asian Pharma Leader (2024)

Challenge: Reduce chemotherapy-induced neuropathy
Solution: 200mg BID oral EGT during treatment cycles
Results: 41% lower neuropathy incidence vs. control group

Technical & Bulk Order Support

For formulation assistance, clinical data packages, or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826

Available Services:
1. Custom particle size optimization (50nm-200µm)
2. Regulatory support (FDA DMF, EU Novel Food)
3. Stability testing programs (ICH Q1A conditions)

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