Idoxuridine CAS 54-42-2

Chemical Name: Idoxuridine
Synonyms: (+)-5-Iodo-2′-deoxyuridine; 2′-Deoxy-5-iodouridine; 5-IdU
CAS No.: 54-42-2
Molecular Formula: C9H11IN2O5
Molecular Weight: 354.1
Appearance: Crystalline powder

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Idoxuridine (CAS 54-42-2) Comprehensive User Guide

1. Product Specifications & Comparative Analysis

Parameter Idoxuridine (CAS 54-42-2) Generic Antiviral Agents
Molecular Formula C9H11IN2O5 Varies
Molecular Weight 354.10 g/mol 200-400 g/mol
Appearance White crystalline powder Liquid/Powder
Solubility 1.6 g/L in water (20°C) Generally higher
Melting Point 194°C 150-200°C
IC50 (FHV-1) 4.3 μM 10-50 μM

2. Key Applications

Therapeutic Uses

  • Primary treatment for herpes simplex keratitis (ocular viral infections)
  • Inhibitor of orthopoxvirus replication
  • Veterinary antiviral applications (e.g., feline herpesvirus type 1)

Research Applications

  • DNA polymerase inhibition studies
  • Viral replication mechanism analysis
  • Reference standard in pharmaceutical QC (USP/EP compliance)

3. Usage Scenarios

Ophthalmic Formulation

0.1% ophthalmic solution applied topically every 1-2 hours during acute phase

Laboratory Protocol

  1. Prepare 10 mM stock solution in DMSO
  2. Dilute in cell culture medium to working concentration
  3. Apply to infected cell lines for 48-72 hours

4. Client Case Studies

Case 1: Pharmaceutical Manufacturer

Client: North China Pharmaceutical Group
Application: USP-grade reference standard production
Outcome: Achieved 99.8% purity for regulatory submissions

Case 2: Veterinary Research Institute

Client: Shenzhen Veterinary Medicine Center
Application: FHV-1 treatment optimization
Outcome: Reduced viral load by 89% in clinical trials

5. Inquiry & Technical Support

For product specifications, COA, or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826

Quality Assurance

  • USP/EP certified batches available
  • HPLC & NMR analytical reports provided
  • Custom synthesis services

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