Thiamine Hydrochloride Cas 70-16-6

Chemical Name: thiamine hydrochloride
Synonyms: Thiamine ion; thiamine hcl; vitamin b1 hcl; aneurin hcl
CAS No.: 70-16-6
Molecular Formula: C12H17N4OS
Molecular Weight: 265.35
Appearance: crystalline powder

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1. Product Overview & Specifications

Thiamine Hydrochloride (CAS 70-16-6)

Parameter Specification Thiamine Derivatives Comparison
Chemical Formula C12H17N4OS Thiamine Monophosphate: C12H18ClN4O4PS
Molecular Weight 265.35 g/mol Fursultiamine: 422.55 g/mol
Appearance White crystalline powder Thiamine Nitrate: Colorless crystals
Solubility 50 mg/mL in water (20°C) Bisbuthiamine: Water-insoluble
Stability pH 2-4 stable; light-sensitive Pyritiamine: Air-sensitive

2. Key Applications

Core Functional Uses

  • Pharmaceuticals: Essential cofactor in carbohydrate metabolism enzymes
  • Food Fortification: WHO-recommended additive for staple foods (0.2-0.5 mg/100g)
  • Clinical Nutrition: IV therapy for Wernicke-Korsakoff syndrome treatment
  • Biochemical Research: Cell culture media component (0.1-1.0 mg/L concentration)

3. Operational Guidelines

Optimal Handling Protocols

Parameter Requirement
Storage Temperature 2-8°C in amber glass containers
Reconstitution Use 0.01M HCl for stock solutions (100x concentration)
pH Range Maintain 3.0-4.5 in aqueous solutions
Shelf Life 24 months unopened; 6 months post-reconstitution

4. Industry Applications

Implementation Scenarios

  • Bakery Products: 0.3mg/100g in wheat flour improves nutritional profile
  • Aquaculture: Shrimp feed additive (50-75mg/kg) Stability Testing Meets ICH Q1A(R2) guidelines for accelerated conditions

5. Client Success Stories

Documented Case Studies

Client Application Outcome
Wond Chemical Co., Ltd Pharmaceutical intermediate production 30% yield improvement through optimized crystallization
Chongqing Biolong Pharma IV nutrition solutions Extended stability from 3 to 18 months
Shanghai Spring Biotech Cell culture media formulation 95% cell viability in mammalian cultures

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