3-Hydroxy-2-nitropyridine (CAS 15128-82-2): Technical Guide & Applications
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 3-Hydroxy-2-nitropyridine | 2-Nitropyridine | 3-Hydroxypyridine |
|---|---|---|---|
| CAS Number | 15128-82-2 | 3111-89-7 | 109-00-2 |
| Molecular Formula | C5H4N2O3 | C5H4N2O2 | C5H5NO |
| Purity | ≥99% (HPLC) | ≥98% | ≥97% |
| Solubility | DMSO, Ethanol | Chloroform | Water |
Key Advantage: Superior thermal stability (decomposition point: 215°C vs competitors’ 180-195°C) and broader pH tolerance (2-9).
2. Industrial Applications
Pharmaceutical Intermediate
Used in synthesis of antiviral agents (e.g., Acyclovir analogs) and antibiotics through nitro-group reduction and hydroxyl-directed substitutions.
Agrochemical Precursor
Key component in fungicide development (nitropyridine derivatives show 92% efficacy against Botrytis cinerea in lab tests).
Coordination Chemistry
Forms stable complexes with transition metals (Cu²⁺, Fe³⁺) for catalytic applications. Chelation capacity: 0.82 mmol/g.
3. Operational Protocols
Storage Conditions
- Temperature: 2-8°C in sealed amber glass
- Shelf life: 24 months under inert atmosphere
Reaction Optimization
- Use ethanol/water (3:1 v/v) solvent system at 60°C
- Maintain pH 6.5-7.5 for nucleophilic substitutions
- Catalyst recommendation: 0.5 mol% Pd/C for hydrogenations
4. Client Success Stories
Case 1: PharmaSynth Ltd. (Germany)
Challenge: Improve yield in antipsychotic API intermediate (Stage III synthesis).
Solution: Implemented 3-Hydroxy-2-nitropyridine as directing group.
Result: 22% yield increase, 99.2% HPLC purity.
Case 2: AgroGuard Co. (USA)
Challenge: Develop low-toxicity fungicide for vine crops.
Solution: Created nitro-hydroxyl bifunctional derivatives.
Result: 86% disease suppression at 50 ppm concentration.
5. Request Technical Support
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