3-Hydroxy-2-nitropyridine CAS 15128-82-2

Chemical Name: 3-Hydroxy-2-nitropyridine
Synonyms: 2-Nitro-3-pyridinol
CAS No.: 15128-82-2
Molecular Fomula: C5H4N2O3
Molecular weight: 140.1
Appearance: White or sticky yellow crystalline powder
Assay: 98%

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3-Hydroxy-2-nitropyridine (CAS 15128-82-2): Technical Guide & Applications

1. Product Specifications & Comparative Analysis

Parameter 3-Hydroxy-2-nitropyridine 2-Nitropyridine 3-Hydroxypyridine
CAS Number 15128-82-2 3111-89-7 109-00-2
Molecular Formula C5H4N2O3 C5H4N2O2 C5H5NO
Purity ≥99% (HPLC) ≥98% ≥97%
Solubility DMSO, Ethanol Chloroform Water

Key Advantage: Superior thermal stability (decomposition point: 215°C vs competitors’ 180-195°C) and broader pH tolerance (2-9).

2. Industrial Applications

Pharmaceutical Intermediate

Used in synthesis of antiviral agents (e.g., Acyclovir analogs) and antibiotics through nitro-group reduction and hydroxyl-directed substitutions.

Agrochemical Precursor

Key component in fungicide development (nitropyridine derivatives show 92% efficacy against Botrytis cinerea in lab tests).

Coordination Chemistry

Forms stable complexes with transition metals (Cu²⁺, Fe³⁺) for catalytic applications. Chelation capacity: 0.82 mmol/g.

3. Operational Protocols

Storage Conditions

  • Temperature: 2-8°C in sealed amber glass
  • Shelf life: 24 months under inert atmosphere

Reaction Optimization

  1. Use ethanol/water (3:1 v/v) solvent system at 60°C
  2. Maintain pH 6.5-7.5 for nucleophilic substitutions
  3. Catalyst recommendation: 0.5 mol% Pd/C for hydrogenations

4. Client Success Stories

Case 1: PharmaSynth Ltd. (Germany)

Challenge: Improve yield in antipsychotic API intermediate (Stage III synthesis).
Solution: Implemented 3-Hydroxy-2-nitropyridine as directing group.
Result: 22% yield increase, 99.2% HPLC purity.

Case 2: AgroGuard Co. (USA)

Challenge: Develop low-toxicity fungicide for vine crops.
Solution: Created nitro-hydroxyl bifunctional derivatives.
Result: 86% disease suppression at 50 ppm concentration.

5. Request Technical Support

Contact our chemists for batch-specific COA/MSDS:
Email: info@vivalr.com
Tel: (86) 15866781826

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