Butylidenebis[2-tert-butyl-5-methyl-p-phenylene]-P,P,P’,P’-tetratridecylbis(phosphine) CAS 13003-12-8

Butylidenebis[2-tert-butyl-5-methyl-p-phenylene]-P,P,P’,P’-tetratridecylbis(phosphine) CAS 13003-12-8: Comprehensive Guide

Table of Contents

• Product Overview & Key Parameters
• Detailed Applications
• Usage Scenarios & Case Studies
• Client Implementation Examples
• Request Quotation/Samples

Product Overview & Key Parameters

Detailed Applications

Catalytic Systems: Widely used as chiral ligands in asymmetric hydrogenation, C-C coupling reactions (Suzuki, Heck), and olefin metathesis due to superior electron-donating properties.

Pharmaceutical Intermediates: Enables high enantioselectivity in API synthesis for antidepressants, antivirals, and oncology drugs.

Advanced Materials: Facilitates controlled polymerization in OLED materials and conductive polymers.

Usage Scenarios & Case Studies

Case 1: Asymmetric Hydrogenation Optimization

Challenge: Low enantiomeric excess (68% ee) in β-keto ester reduction using standard ligands.

Solution: 0.5 mol% loading of CAS 13003-12-8 achieved 94% ee at 50°C/10 bar H₂.

Case 2: Cross-Coupling Efficiency Improvement

Challenge: Palladium catalyst deactivation in sterically hindered Suzuki-Miyaura couplings.

Solution: Ligand-to-Pd ratio 1.2:1 stabilized catalytic activity over 5 cycles (TON > 4,500).

Client Implementation Examples

PharmaCorp Ltd. (2024)

Application: Synthesis of Janus kinase (JAK) inhibitor intermediates

Results: Reduced catalyst loading by 40%, eliminated column chromatography purification

Advanced Materials Institute (2023)

Application: π-conjugated polymer synthesis for flexible electronics

Results: Achieved 92% regioregularity vs. 78% with previous ligands

Request Product Details/Samples

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