Colistin CAS 1066-17-7: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Colistin (CAS 1066-17-7), also known as polymyxin E, is a polypeptide antibiotic effective against Gram-negative bacteria. It is widely used in human and veterinary medicine.
| Parameter | Colistin Sulfate | Colistimethate Sodium |
|---|---|---|
| CAS Number | 1264-72-8 | 8068-28-8 |
| Molecular Formula | C52H98N16O13·2H2SO4 | C58H103N16Na2O16S2 |
| Purity | ≥75% (USP) | ≥150,000 IU/mg |
| Storage | 2-8°C, protected from moisture | |
2. Applications of Colistin
Medical Uses
- Treatment of multidrug-resistant Pseudomonas aeruginosa, Klebsiella, and Acinetobacter infections
- Intravenous/oral administration for systemic infections
- Nebulized form for pulmonary infections
Veterinary Applications
- Swine colibacillosis control
- Poultry E. coli prophylaxis
3. Usage Guidelines
Human Dosage (IV)
| Patient Weight | Loading Dose | Maintenance Dose |
|---|---|---|
| 50-75 kg | 9 million IU | 4.5 million IU q12h |
Preparation Steps
- Reconstitute with sterile water for injection
- Administer via slow IV infusion over 30-60 minutes
- Monitor renal function weekly
4. Case Studies
Case 1: ICU Pneumonia Treatment
Patient: 68-year-old male with ventilator-associated pneumonia caused by carbapenem-resistant Klebsiella pneumoniae.
Regimen: Colistin 4.5 million IU IV q12h + meropenem 2g IV q8h.
Outcome: Clinical improvement within 72 hours; cultures negative at day 7.
5. Client Success Stories
PharmaTech India Pvt. Ltd.
Challenge: Recurrent post-surgical infections in transplant patients.
Solution: Implemented colistin-based combination therapy protocol.
Results: 40% reduction in ICU mortality rates over 6 months.
VetCare Brazil
Challenge: Neonatal piglet mortality due to enterotoxigenic E. coli.
Solution: Oral colistin sulfate at 50 mg/kg feed for 5 days.
Results: 92% survival rate in treated litters vs. 68% control group.
6. Contact for Inquiries
Request product specifications or clinical data:
Email: info@vivalr.com
Tel: (86) 15866781826
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