Protionamide Cas 14222-60-7

Chemical Name: Protionamide
CAS No.:14222-60-7
Molecular Fomula: C9H12N2S
Molecular weight:180.27

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Protionamide (CAS 14222-60-7) Comprehensive Product Guide

Table of Contents

1. Basic Information & Specifications

Parameter Specification
Chemical Name Protionamide
CAS Number 14222-60-7
Molecular Formula C9H12N2S
Therapeutic Class Second-line Antitubercular Agent
Storage Conditions 2-8°C protected from light

2. Clinical Applications

Protionamide demonstrates bacteriostatic activity against Mycobacterium tuberculosis, particularly effective in multidrug-resistant tuberculosis (MDR-TB) regimens. Clinical applications include:

  • Adjunctive therapy in drug-resistant TB cases
  • HIV-associated tuberculosis management
  • Latent TB infection treatment in high-risk populations

3. Therapeutic Agent Comparison

Parameter Protionamide Ethionamide
Bioavailability >90% 85-90%
Half-life 2-3 hours 2-4 hours
Dose Frequency Once daily Twice daily

4. Clinical Case Studies

Case Study 1: MDR-TB Management

A 38-year-old male with pulmonary MDR-TB demonstrated sputum conversion within 8 weeks using protionamide-containing regimen. Treatment protocol included:

  • Protionamide 500mg/day
  • Bedaquiline 400mg daily
  • Linezolid 600mg daily

Case Study 2: Pediatric Application

12-year-old patient with extrapulmonary TB showed complete resolution of lymph node involvement after 6-month therapy with protionamide dose-adjusted regimen (15mg/kg/day).

5. Contact Information

For technical specifications, clinical data sheets, or procurement inquiries:

Email: info@vivalr.com
Phone: (86) 15866781826

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