2-(2-Aminothiazol-4-yl) acetic acid hydrochloride cas 66659-20-9

1. Product Overview & Specifications

2-(2-Aminothiazol-4-yl)acetic acid hydrochloride (CAS 66659-20-9) is a specialized organic compound widely used in pharmaceutical synthesis. Below are its critical parameters:

Comparative Analysis

This compound outperforms similar intermediates in stability and solubility, making it ideal for API synthesis under diverse conditions.

2. Key Applications

Primarily employed as a pharmaceutical intermediate, it serves as a building block in:

• Antibiotic Development: Synthesis of cephalosporin derivatives.
• Anticancer Agents: Construction of thiazole-containing bioactive molecules.
• Enzyme Inhibitors: Tailoring specificity in protease inhibitor design.

3. Usage Guidelines

Handling Protocols

• Use PPE (gloves, goggles, lab coat) in controlled environments.
• Avoid contact with oxidizing agents.

Reaction Optimization

For coupling reactions:

1. Dissolve in anhydrous DMF at 0–5°C.
2. Maintain pH 6.5–7.5 with tertiary amines.
3. Monitor by TLC (R_f 0.3–0.4 in EtOAc/hexane).

4. Industry Case Studies

Case 1: Antibiotic Production

Client: A European pharmaceutical company
Application: Synthesis of β-lactam antibiotics
Outcome: 22% yield increase compared to traditional intermediates.

Case 2: Oncology Research

Client: US biotech firm
Application: Development of kinase inhibitors
Result: Achieved IC₅₀ of 12 nM in preliminary assays.

5. Technical Support & Inquiry

For bulk orders or customized specifications: