6-Methylpyridine-3-Carboxylic Acid (CAS 3222-47-7): Comprehensive Technical Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 6-Methylpyridine-3-carboxylic acid |
| CAS Number | 3222-47-7 |
| Molecular Formula | C7H7NO2 |
| Molecular Weight | 137.14 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 210–213°C |
| Boiling Point | 296.2°C at 760 mmHg |
| Solubility | Sparingly soluble in water |
| Storage | 2–8°C in airtight container |
2. Key Applications
This specialty chemical serves critical functions in:
- Pharmaceutical Synthesis: Key intermediate in production of Etoricoxib (selective COX-2 inhibitor for arthritis treatment)
- Agrochemical Development: Building block for crop protection agents
- Material Science: Precursor for functional polymers and coordination complexes
- Research Chemistry: Chiral ligand in asymmetric catalysis studies
3. Usage Guidelines
Recommended Handling Protocols
- Use PPE (nitrile gloves, safety goggles) during material handling
- Conduct reactions under inert atmosphere for oxygen-sensitive processes
- Optimize reaction temperature between 80–120°C for most coupling reactions
4. Industry Case Studies
Pharmaceutical Intermediate Production
A European API manufacturer achieved 22% yield improvement in Etoricoxib synthesis through optimized purification protocols using 3222-47-7.
5. Client Success Stories
Case 1: Advanced Material Development
Shanghai Pharmaceutical Co. successfully developed a novel metal-organic framework using this compound as a structural template.
Case 2: Process Optimization
Wuhan Fine Chemicals reduced production costs by 18% through improved catalytic systems based on 6-methylnicotinic acid derivatives.
6. Contact for Technical Support
For formulation assistance or bulk purchasing:
- Email: info@vivalr.com
- Tel: (86) 15866781826



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