Diacetonefructose (CAS 20880-92-6): Comprehensive Technical Guide
Table of Contents
1. Key Specifications & Comparative Analysis
| Parameter | Diacetonefructose | Conventional Sugar Derivatives |
|---|---|---|
| CAS Number | 20880-92-6 | N/A |
| Molecular Formula | C12H20O6 | Variable |
| Molecular Weight | 260.28 g/mol | 180-400 g/mol |
| Melting Point | 94-95°C | 80-150°C |
| Boiling Point | 332.6±37.0°C | 200-350°C |
| Solubility | Chloroform, Methanol, Ethyl Acetate | Polar Solvents |
2. Industrial Applications
Diacetonefructose serves as a critical intermediate in pharmaceutical synthesis, particularly for anticonvulsant drugs like Topiramate. Its ketone-protected structure enhances stability during multi-step organic reactions. Key functional advantages include:
- High chiral purity (>99%) for enantioselective synthesis
- Thermal stability up to 300°C
- Low hygroscopicity compared to unprotected sugars
3. Functional Use Cases
Pharmaceutical Synthesis
In Topiramate production, Diacetonefructose undergoes sulfamation followed by ammonolysis to create the drug’s core bicyclic structure. Process benefits:
- Yield improvement: 72% → 89%
- Purity enhancement: <95% → >99.5%
- Reaction time reduction: 18h → 9h
4. Client Implementation Examples
Case Study 1: Shenzhen Xingkaiyue Biotechnology
Application: Bulk API production
Scale: 25 MT/month
Results: Achieved 99.99% HPLC purity through optimized crystallization protocols.
Case Study 2: Xi’an Qicheng Fine Chemicals
Application: Antiepileptic drug intermediates
Scale: 10 MT/month
Results: Reduced production costs by 22% via solvent recycling systems.
5. Procurement Inquiry
For technical specifications, MSDS, or bulk pricing:
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Global shipping available with COA and stability data.



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