Tert-Butyldimethylsilyl Chloride (TBDMSCl) CAS 18162-48-6: Comprehensive Guide
Table of Contents
1. Product Overview & Specifications
Tert-Butyldimethylsilyl Chloride (CAS 18162-48-6) is a silicon-based protecting agent widely used in organic synthesis. Key parameters:
| Parameter | TBDMSCl | Competitor A | Competitor B |
|---|---|---|---|
| Purity | ≥99% | ≥97% | ≥95% |
| Storage Temp | 2-8°C | Ambient | -20°C |
| Moisture Sensitivity | Low | High | Moderate |
2. Key Applications
- Protection of hydroxyl groups in carbohydrate chemistry
- Intermediate in nucleoside analog synthesis
- Steric shielding agent in peptide synthesis
- Selective silylation in complex molecule construction
3. Usage Guidelines
Case Study: Protecting Labile Alcohol Groups
Step 1: Dissolve 1.2 eq TBDMSCl in anhydrous DMF
Step 2: Add 1.0 eq imidazole catalyst
Step 3: React at 0°C for 4 hours
Result: >90% protection yield with minimal side reactions
4. Customer Success Stories
Case 1: PharmaTech Solutions (Shanghai)
Challenge: Degradation of antiviral intermediates during storage
Solution: TBDMSCl protection of critical hydroxyl groups
Outcome: 68% stability improvement at 6-month accelerated testing
Case 2: BioSyntech GmbH (Berlin)
Challenge: Low selectivity in steroid derivatization
Solution: Sequential TBDMSCl/TMSCl protection strategy
Outcome: 92% regioselectivity achieved
5. Request Customized Solutions
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