Potassium Bis(trimethylsilyl)amide (CAS 40949-94-8) Comprehensive Guide 2025
Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Industrial Uses
- 3. Performance Comparison Chart
- 4. Operational Guidelines & Safety Protocols
- 5. Industry Case Studies
- 6. Technical Consultation & Quotation
1. Product Overview & Specifications
| Parameter | Potassium Bis(trimethylsilyl)amide | Similar Reagents |
|---|---|---|
| CAS Number | 40949-94-8 | N/A |
| Molecular Formula | C6H18KNSi2 | Varies by compound |
| Appearance | White crystalline powder | Liquid/Powder variants |
| Storage Temperature | 2-8°C (under inert gas) | Room temp for some analogs |
2. Key Applications & Industrial Uses
Primary functional roles:
- Strong non-nucleophilic base for deprotonation reactions
- Catalyst in organometallic synthesis
- Essential reagent in pharmaceutical intermediates production
- Silicon-based protective group installation
3. Performance Comparison Chart
| Feature | KHMDS | NaHMDS | LiHMDS |
|---|---|---|---|
| Base Strength (pKa) | 26 | 25.5 | 25.8 |
| Solubility in THF | High | Moderate | Excellent |
| Reaction Temperature | -78°C to 25°C | -30°C to 40°C | -78°C to 0°C |
4. Operational Guidelines & Safety Protocols
Critical handling requirements:
- Maintain strict inert atmosphere (Ar/N2)
- Use anhydrous solvents (H2O < 50ppm)
- Emergency neutralization protocol: IPA/H2O mixture
5. Industry Case Studies
Case 1: Pharmaceutical Intermediate Synthesis
Client: EuroPharma Solutions GmbH
- Application: Steroid derivative alkylation
- Result: 92% yield improvement vs traditional methods
- Scale: 150kg batch production
Case 2: OLED Material Development
Client: AsiaOpto Materials Co., Ltd.
- Application: Electron transport layer synthesis
- Result: 15% efficiency increase in final devices
- Purity Requirement: 99.95%+
6. Technical Consultation & Quotation
Contact our chemical engineering team for:
- Bulk pricing (25kg+ drum quantities)
- Custom purity specifications (99.9%-99.999%)
- GMP-grade manufacturing options
Email: info@vivalr.com
Tel: (86) 15866781826
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