Piperazine (CAS 110-85-0) Technical Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification | Comparison with Derivatives |
|---|---|---|
| Chemical Formula | C4H10N2 | Base compound (vs. phosphate/citrate salts) |
| Molecular Weight | 86.14 g/mol | Lower than citrate (202.15 g/mol) |
| Appearance | White crystalline solid | Different from liquid derivatives |
| Melting Point | 109.6°C | Higher than citrate salts |
| Solubility | Water: 150 g/L (20°C) | Better than phosphate derivatives |
2. Key Applications
Pharmaceutical Manufacturing
- Primary intermediate for antihelminthic drugs (Piperazine Phosphate/Citrate)
- Synthesis of antipsychotics: Fluorophenazine derivatives
- Production of Rifampin anti-TB medications
Industrial Applications
- Corrosion inhibitor in cooling systems
- Polymer stabilizer in resin production
- Precursor for specialty surfactants
3. Industrial Use Cases
Case 1: Pharmaceutical Synthesis
Process: Alkylation reaction with 2,3-dichlorobromobenzene using Ullmann coupling
Output: 1-(2,3-dichlorophenyl)piperazine (antipsychotic intermediate)
Case 2: Water Treatment
Application: Scale inhibition in industrial boilers at 0.5-1.2% concentration
Result: 40% reduction in calcium carbonate deposition
4. Safety & Handling Protocols
| Hazard | Protection Measures | Emergency Response |
|---|---|---|
| Corrosive (pH 12.3) | Chemical-resistant gloves (Butyl rubber) | 15 min flush with water for skin contact |
| Respiratory Irritant | NIOSH-approved N95 respirator | Oxygen therapy if inhaled |
| Environmental Hazard | Secondary containment systems | Neutralize with 5% acetic acid |
5. Client Success Stories
PharmaTech Solutions (Nanjing)
Application: Bulk production of Piperazine Citrate
Outcome: Achieved 99.5% purity using recrystallization optimization
PolyChem Industries (Shanghai)
Application: Development of heat-resistant epoxy resins
Result: 25% improvement in thermal stability at 180°C
6. Supplier Information
| Supplier | Specification | Contact |
|---|---|---|
| CRS Biochemical | Pharma Grade (99.9%) | Tel: (86) 15866781826 Email: info@vivalr.com |
| Macklin Inc. | Lab Reagent (95-99%) | Tel: 021-50706066 |
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