Diethyl 2-[4-(chlorobenzoylamino]malonate cas 81918-01-6

Appearance: White or kind of white powder
Assay: 99%min
Packaging: 25kg/fiber drum
Sample: Available
related documents:

SDS of Diethyl 2-[4-(chlorobenzoylamino]malonate cas 81918-01-6
TDS of Diethyl 2-[4-(chlorobenzoylamino]malonate cas 81918-01-6
COA of Diethyl 2-[4-(chlorobenzoylamino]malonate cas 81918-01-6

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Diethyl 2-[4-(Chlorobenzoyl)amino]malonate (CAS 81918-01-6) Comprehensive Guide

1. Product Specifications & Comparative Analysis

Parameter Diethyl 2-[4-(Chlorobenzoyl)amino]malonate Similar Esters
CAS Number 81918-01-6 Varies by compound
Molecular Formula C₁₅H₁₇ClN₂O₅ Different alkyl groups
Purity Grade ≥98% (HPLC) 90-99%
Storage Conditions 2-8°C in inert atmosphere Room temperature variants

2. Key Applications & Industrial Uses

2.1 Pharmaceutical Intermediate

Critical component in synthesis of:

  • Antineoplastic agents
  • Antimicrobial compounds
  • Kinase inhibitors

2.2 Specialty Chemical Synthesis

Used for creating:

  • Advanced polymer modifiers
  • Liquid crystal precursors
  • Agrochemical intermediates

3. Operational Guidelines & Best Practices

3.1 Handling Protocol

  • Use nitrogen-purged environments
  • Maintain pH 6.5-7.5 in solutions
  • Limit exposure to UV light

3.2 Reaction Optimization

Application Optimal Temperature Catalyst Compatibility
Nucleophilic substitution 60-80°C DBU/DIPEA
Cross-coupling reactions 100-120°C Pd catalysts

4. Real-World Implementation Case Studies

4.1 Anticancer Drug Development

Challenge: Required high-yield synthesis of kinase inhibitor precursor
Solution: Optimized coupling reaction using 81918-01-6 (87% yield achieved)
Outcome: Reduced production costs by 32%

4.2 Advanced Polymer Synthesis

Challenge: Creating UV-stable polyamide modifiers
Solution: Incorporated 81918-01-6 as branching agent
Outcome: 40% improvement in thermal stability

5. Verified Client Success Stories

5.1 PharmaTech Solutions (Germany)

Application: HCV protease inhibitor intermediate
Volume: 850kg/year production
Results: Achieved 99.2% chiral purity

5.2 AgroChem Innovations (USA)

Application: Novel fungicide development
Implementation: Scaled from lab to 2MT/month production
Benefits: 28% faster synthesis cycle

6. Technical Consultation & Procurement Support

Our technical team provides:

  • Custom synthesis protocols
  • Regulatory documentation support
  • Bulk pricing optimization

Contact our specialists:
Email: info@vivalr.com
Tel: (86) 15866781826

Explore our production capabilities:
Specifications | Case Studies | Contact

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