pentafluorophenol cas 771-61-9

Chemical Name: Pentafluorophenol
CAS No.: 771-61-9
Molecular Fomula: C6HF5O
Molecular weight: 184.06
Appearance:White crystalline solid
Assay: 99%min

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Table of Contents

Pentafluorophenol (CAS 771-61-9) Technical Overview

Basic Properties

Parameter Value
CAS Number 771-61-9
Molecular Formula C6HF5O
Molecular Weight 184.06 g/mol
Appearance White crystalline powder
Purity ≥99% (HPLC)
Melting Point 35-38°C
Boiling Point 205-207°C
Flash Point 93°C

Comparative Analysis with Fluorophenol Derivatives

Compound CAS Reactivity Thermal Stability Applications
Pentafluorophenol 771-61-9 High Excellent Pharmaceutical intermediates
Tetrafluorophenol 771-40-4 Moderate Good Polymer modification
Trifluorophenol 827-52-1 Low Fair Agrochemical synthesis

Industrial Applications of Pentafluorophenol

Pharmaceutical Manufacturing

Critical intermediate for HIV protease inhibitors and anticancer drugs. Enables precise fluorine substitution in molecular design.

Organic Synthesis

Preferred activating agent for:
– Peptide coupling reactions
– Esterification catalysts
– Nucleophilic substitution reactions

Material Science

Key component in:
– Liquid crystal polymers
– Fluorinated epoxy resins
– High-performance coatings

Operational Guidelines

Handling Protocols

Parameter Requirement
Storage Temperature 2-8°C (under inert gas)
Shelf Life 24 months in original packaging
Reaction Solvents DCM, THF, DMF (anhydrous)
Safety Equipment Chemical goggles, PTFE gloves

Documented Success Cases

Case 1: European Pharma Company

Challenge: Improve yield in antiviral drug intermediate synthesis
Solution: Implemented pentafluorophenol-mediated coupling
Result: 22% yield increase, 99.5% purity achieved

Case 2: Asian Material Supplier

Challenge: Develop heat-resistant fluoropolymer coating
Solution: Used as crosslinking agent in resin formulation
Result: 300°C thermal stability, 50% faster curing

Request Professional Support

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– Bulk ordering (100kg+ quantities)
– Technical documentation support
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Contact our chemical experts:
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Tel: (86) 15866781826

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