tetrabutylammonium bromide cas 1643-19-2

Chemical Name: Tetrabutylammonium bromide
CAS No: 1643-19-2
Molecular Formula: C16H36BrN
Molecular Weight: 322.37
Appearance: White crystalline powder.
Assay: 99%min

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Tetrabutylammonium Bromide (CAS 1643-19-2): Technical Guide & Industry Applications

1. Product Overview & Specifications

Parameter Tetrabutylammonium Bromide Tetraethylammonium Bromide
CAS Number 1643-19-2 71-91-0
Molecular Formula C16H36BrN C8H20BrN
Molecular Weight 322.37 g/mol 210.16 g/mol
Appearance White hygroscopic crystals White crystalline powder
Melting Point 102-106°C 285°C (dec.)
Water Solubility 600 g/L (20°C) 1,430 g/L (20°C)

2. Key Applications & Functional Uses

Core Industrial Functions:

  • Phase Transfer Catalyst: Enables reactions between immiscible phases in pharmaceutical synthesis
  • Ion-Pairing Reagent: Critical for HPLC analysis of ionic compounds
  • Pharmaceutical Intermediate: Used in synthesis of Bacampicillin, Sultamicillin, and Dapagliflozin
  • Electrochemical Applications: Electrolyte additive in battery systems

Performance Advantages:

  • Superior catalytic efficiency in nucleophilic substitution reactions
  • Enhanced reaction rates under mild conditions
  • Compatible with polar aprotic solvents (DMF, DMSO)

3. Operational Case Studies

Case 1: Antibiotic Synthesis Optimization

A European pharmaceutical manufacturer achieved 38% yield improvement in Bacampicillin production through TBAB-mediated phase transfer catalysis, reducing reaction time from 12h to 6h at 60°C.

Case 2: HPLC Method Development

Analytical laboratory validated a USP-compliant method for ionic drug quantification using 10mM TBAB in mobile phase (ACN:buffer 65:35), achieving resolution >2.0 for critical pairs.

4. Industry Client Implementations

Client A: Hubei Changxinsheng Chemical Co., Ltd.

  • Application: Bulk API synthesis for diabetes medications
  • Scale: 500kg/month TBAB consumption
  • Result: 22% reduction in side products vs. traditional catalysts

Client B: Shandong Jinyueyuan New Materials

  • Application: Lithium-ion battery electrolyte formulation
  • Specification: 99.5% purity, <50ppm moisture
  • Outcome: 15% improvement in battery cycle life

5. Technical Support & Inquiry

For technical specifications, bulk pricing, or customized solutions:

Request product samples or MSDS documentation through our 24-hour response service.

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