D-Leucine (CAS 328-38-1): Comprehensive Technical Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | D-Leucine | L-Leucine |
|---|---|---|
| CAS Number | 328-38-1 | 61-90-5 |
| Molecular Formula | C6H13NO2 | C6H13NO2 |
| Molecular Weight | 131.17 g/mol | 131.17 g/mol |
| Optical Rotation | -15.45° (C=4, H2O) | +15.1° (C=4, H2O) |
| Melting Point | >300°C | 293°C |
| Solubility | 24 g/L (25°C in H2O) | 22.4 g/L (25°C in H2O) |
2. Key Applications
Biomedical Research
Demonstrates superior anti-epileptic activity compared to L-leucine, effectively terminating seizure activity without sedative effects in preclinical models.
Pharmaceutical Development
Used in chiral drug synthesis and as a building block for peptide-based therapeutics targeting neurological disorders.
Biochemical Studies
Critical for protein structure-function analysis and enzyme-substrate interaction studies due to its stereospecific properties.
3. Usage Scenarios
In Vitro Neuroprotection Studies
Applied at 10-100 μM concentrations to modulate neuronal receptor activity while maintaining basal synaptic transmission.
Epilepsy Model Systems
Administered in rodent models at 50 mg/kg doses, showing comparable efficacy to diazepam in seizure suppression.
4. Client Case Studies
Neuropharma Research Institute
Implemented D-Leucine in high-throughput screening of novel antiepileptic agents, achieving 40% faster lead compound identification.
Biotech Peptide Solutions
Utilized in chiral peptide synthesis for blood-brain barrier penetrating therapeutics, improving product purity by 15%.
5. Technical Inquiry
For technical specifications, bulk pricing, or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826



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