1. Chemical Properties & Specifications

2. Mechanism of Action & Applications

Key Mechanisms:

• DNA Alkylation: Generates methyl carbonium ions that crosslink DNA strands (IC₅₀ = 11.7 μg/mL in HL60 leukemia cells)
• β-Cell Toxicity: Selectively destroys pancreatic islet cells via GLUT2 transporter uptake

Primary Applications:

3. Experimental Protocols & Case Studies

Diabetes Model Protocol (Rodents):

1. Fast animals for 12 hours pre-injection
2. Prepare fresh solution in citrate buffer (pH 4.5)
3. Administer intraperitoneally: 55-65 mg/kg for type 1, 35 mg/kg for type 2 models
4. Monitor blood glucose >250 mg/dL for 72h to confirm success

Leukemia Research Case:

In HL60 human myeloid leukemia cells, STZ demonstrated superior cytotoxicity (IC₅₀ = 11.7 μg/mL) compared to alloxan (IC₅₀ = 2,809 μg/mL), making it preferred for hematological malignancy studies.

4. Supplier Comparison & Pricing

5. Client Success Stories

Case 1: Metabolic Research Institute

Generated 92% successful T2D models in mice using 35mg/kg STZ + 12-week high-fat diet protocol. Achieved stable hyperglycemia (>300 mg/dL) for 6-month study duration.

Case 2: Oncology Center Shanghai

Validated STZ’s selective toxicity in GLUT2+ neuroendocrine tumors, showing 73% tumor mass reduction vs controls in xenograft models (p < 0.01).